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Volume 123, Issue 2, Pages (August 2002)

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Presentation on theme: "Volume 123, Issue 2, Pages (August 2002)"— Presentation transcript:

1 Volume 123, Issue 2, Pages 450-460 (August 2002)
Use of surrogate markers of inflammation and Rome criteria to distinguish organic from nonorganic intestinal disease  Jeremy A. Tibble, Gudmundur Sigthorsson, Russell Foster, Ian Forgacs, Ingvar Bjarnason  Gastroenterology  Volume 123, Issue 2, Pages (August 2002) DOI: /gast Copyright © 2002 American Gastroenterological Association Terms and Conditions

2 Fig. 1 Principal symptoms for which patients were referred according to the final diagnostic group. Gastroenterology  , DOI: ( /gast ) Copyright © 2002 American Gastroenterological Association Terms and Conditions

3 Fig. 2 Dot plot of fecal calprotectin levels in the different diagnostic groups. The cutoff value for normality (10 mg/L) is shown by the horizontal line. The calprotectin levels in all organic diagnostic groups except those with diabetic diarrhea differed significantly (P = to <0.0001) from those in the IBS group. Gastroenterology  , DOI: ( /gast ) Copyright © 2002 American Gastroenterological Association Terms and Conditions

4 Fig. 3 ROC for fecal calprotectin identifying patients with organic disease. At the cutoff value for normality (10 mg/L), fecal calprotectin has a sensitivity of 89% and specificity of 79% for organic disease. Gastroenterology  , DOI: ( /gast ) Copyright © 2002 American Gastroenterological Association Terms and Conditions

5 Fig. 4 ROC for intestinal permeability identifying patients with organic small intestinal disease. At the cutoff value for normality (0.05), intestinal permeability has a sensitivity of 63% and specificity of 87% for organic small intestinal disease. Gastroenterology  , DOI: ( /gast ) Copyright © 2002 American Gastroenterological Association Terms and Conditions


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