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Blood oxygen level–dependent measurement of acute intra-renal ischemia

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1 Blood oxygen level–dependent measurement of acute intra-renal ischemia
Laurent Juillard, Lilach O. Lerman, David G. Kruger, John A. Haas, Brian C. Rucker, Jason A. Polzin, Stephen J. Riederer, Juan C. Romero  Kidney International  Volume 65, Issue 3, Pages (March 2004) DOI: /j x Copyright © 2004 International Society of Nephrology Terms and Conditions

2 Figure 1 Logarithm of MR signal as a function of echo time. A representative BOLD signal measurement (/s) in both kidneys of a pig at total occlusion of one renal artery. Calculated slope are given in parentheses. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions

3 Figure 2 R2* BOLD-derived signal measurement (1/sec) at baseline (BL), at the lower limit of RBF autoregulation (AR), with RBF at 80% to 0% RBF at baseline (S80 to S0), after 5, 10, and 15 minutes of recovery (R5 to R15), and after furosemide injection (FR). Obstructed cortex (OC), •; contralateral cortex (CLC), ▪; obstructed medulla (OM), ♦; contralateral medulla (CLM), ▴. *P < 0.05 vs. baseline; §P < 0.05 vs. recovery. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions

4 Figure 3 Mean ± SEM of (A) urine flow (mL/min), (B) glomerular flow rate (GFR, mL/min), (C) effective renal plasma flow (ERPF, mL/min); (D) tubular sodium reabsorption (mmol/min), and (E) oxygen consumption (mLO2/min). Interventions are baseline (BL), RBF in the lower limit of RBF autoregulation (AR), RBF at 80% to 0% RBF at baseline (S80 to S0), after 5, 10, and 15 minutes of recovery (R5 to R15), and after furosemide injection (FR). Right obstructed (Obs) kidney, •, left intact contralateral (CL) kidney, ▪. *P < 0.05 vs. baseline. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions

5 Figure 3 Mean ± SEM of (A) urine flow (mL/min), (B) glomerular flow rate (GFR, mL/min), (C) effective renal plasma flow (ERPF, mL/min); (D) tubular sodium reabsorption (mmol/min), and (E) oxygen consumption (mLO2/min). Interventions are baseline (BL), RBF in the lower limit of RBF autoregulation (AR), RBF at 80% to 0% RBF at baseline (S80 to S0), after 5, 10, and 15 minutes of recovery (R5 to R15), and after furosemide injection (FR). Right obstructed (Obs) kidney, •, left intact contralateral (CL) kidney, ▪. *P < 0.05 vs. baseline. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions


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