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From: General Anesthetics Modify the Kinetics of Nicotinic Acetylcholine Receptor Desensitization at Clinically Relevant Concentrations  Anesthes. 1995;82(1):276-287.

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Presentation on theme: "From: General Anesthetics Modify the Kinetics of Nicotinic Acetylcholine Receptor Desensitization at Clinically Relevant Concentrations  Anesthes. 1995;82(1):276-287."— Presentation transcript:

1 From: General Anesthetics Modify the Kinetics of Nicotinic Acetylcholine Receptor Desensitization at Clinically Relevant Concentrations  Anesthes. 1995;82(1): Figure Legend: Figure 6. Fractional amplitude (A) and apparent rate (B) of the first component after mixing Dns-C6-Cho with membranes containing the AcChoR. Final concentrations were 2.0 micro Meter Dns-C6-Cho and 0.4 micro Meter agonist binding sites. EC50S for increasing the fractional amplitude of this component are 2.3 plus/minus 0.8 mM and 80 plus/minus 1.4 mM with Hill coefficients of 3.3 plus/minus 0.36 and 4.7 plus/minus 0.34 for isoflurane and butanol, respectively. (B) EC50S for decreasing the apparent rate of this component are 2.3 plus/minus 0.19 mM and 76 plus/minus 4.1 mM with Hill coefficients of -5 plus/minus 1.5 and -3.2 plus/minus 0.50 for isoflurane and butanol, respectively. Date of download: 10/24/2017 Copyright © 2017 American Society of Anesthesiologists. All rights reserved.

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