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DRUG DISCOVERY: FINDING A LEAD

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Presentation on theme: "DRUG DISCOVERY: FINDING A LEAD"— Presentation transcript:

1 DRUG DISCOVERY: FINDING A LEAD
Patrick An Introduction to Medicinal Chemistry 3/e Chapter 9 DRUG DISCOVERY: FINDING A LEAD Part 3: Section 9.4 (Lead compounds from the synthetic world)

2 Contents Part 3: Section Lead compounds from the synthetic world 4.4. Lead Compounds from the Synthetic World - Organic Synthesis - Combinatorial Synthesis - Combinatorial Synthesis - Peptide Synthesis - Combinatorial Synthesis - Heterocyclic Synthesis (5 Slides) [14 slides]

3 SYNTHETIC COMPOUNDS
4.4 Lead Compounds from the Synthetic World SYNTHETIC COMPOUNDS SYNTHETIC COMPOUNDS MOR008C.WAV

4 4.4 Lead Compounds from the Synthetic World
PRONTOSIL

5 4.4 Lead Compounds from the Synthetic World
SULFANILAMIDE

6 4.4 Lead Compounds from the Synthetic World
TNT

7 4.4 Lead Compounds from the Synthetic World
RUBBER INDUSTRY ANTABUSE

8 4.4 Lead Compounds from the Synthetic World
ORGANIC SYNTHESIS

9 4.4 Lead Compounds from the Synthetic World
COMBINATORIAL SYNTHESIS AUTOMATED SYNTHETIC MACHINES

10 4.4 Lead Compounds from the Synthetic World
COMBINATORIAL SYNTHESIS - PEPTIDE SYNTHESIS AMINO ACID RESIN BEAD AMINO ACIDS X PEPTIDE

11 4.4 Lead Compounds from the Synthetic World
COMBINATORIAL SYNTHESIS - HETEROCYCLIC SYNTHESIS RESIN BEAD N N Y CHR1R2 O

12 4.4 Lead Compounds from the Synthetic World
COMBINATORIAL SYNTHESIS - HETEROCYCLIC SYNTHESIS N N RESIN BEAD R2 R3 O H

13 4.4 Lead Compounds from the Synthetic World
COMBINATORIAL SYNTHESIS - HETEROCYCLIC SYNTHESIS N N RESIN BEAD R2 R3 O R4 EtO R5 O

14 4.4 Lead Compounds from the Synthetic World
COMBINATORIAL SYNTHESIS - HETEROCYCLIC SYNTHESIS N N RESIN BEAD R2 R3 N R4 HN R5 O

15 4.4 Lead Compounds from the Synthetic World
COMBINATORIAL SYNTHESIS - HETEROCYCLIC SYNTHESIS RESIN BEAD N N Y R2 R3 N R4 HN R5 O


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