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Animal model for Graves disease

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Presentation on theme: "Animal model for Graves disease"— Presentation transcript:

1 Animal model for Graves disease
Animal model for Graves disease. This first animal model of Graves-like disease was achieved by injecting AKR/N mice with syngeneic (MHC-identical) fibroblasts dually transfected with mouse MHC class II (H2-k) and human TSH-R cDNA. About 25% of the animals developed endocrinologic (hyperthyroidism) and immunologic (TSI, TBII) features of Graves disease. Source: Endocrine Autoimmunity, Greenspan's Basic & Clinical Endocrinology, 10e Citation: Gardner DG, Shoback D. Greenspan's Basic & Clinical Endocrinology, 10e; 2017 Available at: Accessed: October 23, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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