1. PowerPoint Presentation to accompany Hole’s Human Anatomy and Physiology, 9/e by Shier, Butler, and Lewis

2. Chapter 7
Skeletal System

3. Bone Classification Bones are classified according to shape
Long bones are long with expanded ends, Ex: forearm and thigh bone
Short bones are cube like, Ex: wrist, ankle
Flat bones are broad and plate like, Ex: ribs, scapulae, and some skull bones
Irregular bones vary in shape, Ex: vertebrae
Sesamoid or round bones are small bones embedded in tendons, Ex: kneecap (patella)

4. Parts of Bone
Epiphysis: end of the bone which articulates (forms a joint) with another bone.
The epiphyses are composed of spongy bone and covered with hyaline cartilage called articular cartilage.
Figure 7.2

5. Parts of Bone
Diaphysis: shaft of the bone between the epiphyses, composed of compact bone with a medullary cavity in the center.

6. Parts of Bone
Periosteum: fibrous tissue covering of the bone.

7. Compact Bone
Osteocytes and layers of intercellular material lie in concentric rings around an osteonic canal.
This unit is called an osteon or Haversian system.
Osteonic canals contain blood vessels and nerve fibers and are interconnected by transverse perforating (Volkmann’s) canals.

8. Spongy Bone Osteocytes lie within trabeculae, branching bony plates.
Nutrients diffuse into canaliculi that lead to the trabeculae.

9. Bone Growth and Development
The skeletal system begins to form during the first weeks of prenatal development.
Some bones originate within sheets of connective tissue (intramembranous bones).
Some bones begin as models of hyaline cartilage that are replaced by bone (endochrondral bones).

10. Intramembranous Bones
Broad, flat skull bones are intramembranous bones.
During osteogenesis layers of primitive, connective tissue supplied with blood vessels appear at the site of future bone.

11. Intramembranous Bones
Cells differentiate into osteoblasts (bone-building cells) which deposit spongy bone.
Osteoblasts become osteocytes when surrounded by bony matrix in lacunae.

12. Intramembranous Bones
Connective tissue on the surface of the bone forms the periosteum.
Osteoblasts on the inside of the periosteum deposit compact bone over spongy bone.
This process is called intramembranous ossification.

13. Endochondral Bones
Hyaline cartilage forms a model of the bone during embryonic development.
Cartilage degenerates, periosteum forms.
Periosteal blood vessels and osteoblasts invade the bone forming a primary ossification center in the diaphysis.
Secondary ossification centers develop in the epiphyses.

14. Endochondral Bones
Osteoblasts form spongy bone in the space occupied by cartilage.
Osteoblasts become osteocytes when bony matrix surrounds them.

15. Endochondral Bones
Osteoblasts beneath the periosteum deposit compact bone around spongy bone.
A band of cartilage remains between the diaphysis and epiphyses as the epiphyseal disk.

16. Bone Growth
Growth of long bones occurs along four layers of cartilage in the epiphyseal disk.
First Layer: resting cells that do not grow.
Second Layer: young mitotic cells.
Third Layer: older cells that enlarge.
Fourth Layer: dead cells and calcified intercellular substances.

17. Bone Homeostasis
After bone formation, osteoclasts and osteoblasts continue to remodel the bone.
Resorption and deposition are regulated to keep bone mass constant.

18. Nutrition and Bone Development
Vitamin D is necessary to absorb calcium in the small intestine.
Vitamin D deficiency leads in rickets in children and osteomalacia in adults.

19. Nutrition and Bone Development
Vitamin A is necessary for osteoblast and osteoclast activity.
Vitamin C is necessary for collagen synthesis.

20. Hormones and Bone
Growth Hormone (GH) stimulates epiphyseal cartilage cell division.
Deficiency of G H: pituitary dwarfism. Excess GH: pituitary gigantism in children and acromegaly in adults.

21. Hormones and Bone
Thyroid hormone stimulates cartilage replacement in the epiphyseal disks.
Sex steroids promote formation of bone tissue close the epiphyseal disk.

22. Physical Factors Affecting Bone
Physical stress stimulates bone growth.
Weight bearing exercise stimulates bone tissue to thicken and strengthen (hypertrophy).
Lack of exercise leads to bone wasting (atrophy).

23. Bone Function Bones shape, support, and protect body structures.
Bones act as levers to create body movement with muscles.
Bones house blood cell producing tissue.
Bones store inorganic salts.

24. Support and Protection
Bones give shape to the head, face, chest, and limbs.
Bones of the skull protect structures like the eyes, ears, and brain.
Bones of the rib cage and shoulder protect the heart and lungs.
Bones of the pelvic girdle protect the abdominal and reproductive organs.

25. Body Movement
When body parts move, bones and muscle act as levers.

26. Body Movement
A lever has four parts: a bar, a fulcrum, an object moved, a force to supply energy.
There are three classes of levers.
Figure 7.13

27. Body Movement

28. Body Movement

29. Body Movement
Figure 7.14

30. Body Movement

31. Fracture Repair
Blood escapes from damaged blood vessels and forms a hematoma.
Spongy bone forms in regions near blood vessels and fibrocartilage forms farther away.
A bony callus replaces the fibrocartilage.
Osteoclasts remove excess bony tissue, restoring new bone much like the original.

32. Blood Cell Formation
Blood cell formation (hematologists) occurs in yolk sac in early development.
Later it occurs in the liver and spleen.
In the adult red and white blood cells are formed in the red bone marrow.

33. Blood Cell Formation
Red marrow fills the cavity in the diaphesis of the long bones in infants. In adults it is replaced with yellow marrow (fat).
Adult red marrow is found in spongy bone of the skull, ribs, sternum, vertebrae, pelvis.

34. Inorganic Salt Storage
Salts account for 70% of the bone matrix.
These salts are mostly calcium phosphate crystals called hydroxyapatite.

35. Inorganic Salt Storage
Parathyroid hormone stimulates osteoclasts to break down bone when Ca levels are low.
Calcitonin stimulates osteoblasts to build bone when Ca levels are high.
Bone contains Mg, Na, K, and carbonate ions.

36. Axial Skeleton
The skeleton has two divisions: the axial and the appendicular skeleton.
The axial skeleton consists bones that support organs of the head, neck, and trunk.
Skull :cranium and facial bones.
Hyoid bone.
Vertebral column.
Thoracic cage: ribs and sternum.

37. Appendicular Skeleton
The appendicular skeleton consists of the bones of the limbs and bones that anchor the limbs to the axial skeleton.
Pectoral girdle: scapula, clavicle.
Upper limbs: humerus, radium, ulna, carpals, metacarpals, phalanges.
Pelvic girdle: coxal bones.
Lower limbs: femur, tibia, fibula, patella, tarsals, metatarsals, phalanges.

38. Figure 7.17

39. Figure 7.17

40. Cranium Frontal bone: forehead Parietal bones: top of the skull
Occipital bone: back of the skull
Temporal bones: side of skull, near ears
Sphenoid bone:base of the cranium
Ethmoid bone: roof of the nasal cavity

41. Figure 7.19

42. Figure 7.19

43. Figure 7.21

44. Figure 7.21

45. Figure 7.22

46. Figure 7.22

47. Facial Skeleton Maxillary bones: upper jaw, hard palate
Palatine bones: hard palate, nasal cavity
Zygomatic bones: cheek bones
Lacrimal bones: orbit of the eye
Nasal bones: bridge of the nose
Vomer bone: nasal septum
Nasal conchae:walls of the nasal cavity
Mandible: lower jaw

48. Figure 7.29

49. Figure 7.29

50. Figure 7.29

51. Infantile Skull The skull at birth is not fully developed.
Fibrous membranes, fontanels, connect the cranial bones.
The fontanels allow movement of the bones to enable the skull to pass through the birth canal.
The fontanels close as cranial bones grow.

52. Figure 7.33

53. Figure 7.33

54. Vertebral Column
Cervical vertebrae: seven vertebrae of the neck, includes atlas and axis
Thoracic vertebrae: twelve vertebrae that articulate with the ribs
Lumbar vertebrae: five vertebrae that make up the small of the back

55. Vertebral Column Figure 7.34
Sacrum: five vertebrae that fuse in early adulthood, part of the pelvis
Coccyx: four small fused vertebrae
Figure 7.34

56. Thoracic Cage
Ribs: twelve pair of ribs attached to each thoracic vertebrae.
Seven pairs: true ribs and attach to the sternum by costal cartilage.
Two pairs: false ribs that attach to cartilage.

57. Thoracic Cage
Two pairs: floating ribs that do not attach to the sternum or its cartilage.
Sternum: the manubrium, the body, and the xyphoid process.

58. Pectoral Girdle
Clavicles: collar bones that attach the sternum to the shoulder anteriorly.
Scapulae: shoulder blades with two processes.
Acromion process: tip of the shoulder.
Coracoid process: attaches to the clavicle and provides attachments for muscles.
Glenoid fossa articulates with the humerus.

59. Figure 7.42

60. Upper limb
Humerus: upper arm bone, articulates with the glenoid fossa of the scapula

61. Upper limb
Radius: thumb side of the forearm, articulates with the capitulum of the humerus and the radial notch of the ulna
Ulna: longer bone of the forearm, olecranon and coronoid processes articulate with the humerus

62. Hand Carpal bones: eight small bones of the wrist.
Metacarpal bones: five bones, the framework of the palm.
Phalanges: finger bones, three in each finger (proximal, middle, distal phalanx), two in the thumb.

63. Figure 7.47

64. Pelvic Girdle
Coxal bones: two hips bones composed of three fused bones.
Ilium: superior part of the coxal bone.
Ischium: lowest portion of the coxal bone.
Pubis: anterior part of the coxal bone. The two pubic bones joint at the symphysis pubis.

65. Figure 7.49

66. Figure 7.49

67. Male and Female Pelvis Female iliac bones are more flared.
The female pubic arch angle is greater.
There is a greater distance between the ischial spines and tuberosities in the female.
The sacral curvature is shorter and flatter.
The differences create a wider pelvic cavity.

68. Figure 7.51

69. Lower Limb Femur: thigh bone, longest bone
Patella: kneecap, located in a tendon, femur, tibia, and patella form the knee joint
Tibia: shinbone, lateral malleolus forms the ankle
Fibula: slender bone lateral to the tibia, not part of the knee joint

70. Figure 7.52

71. Foot
Tarsal bones: seven small bones in the ankle. The calcaneus (heel bone) is the largest, located below the talus.
Metatarsal bones: elongated bones that form the arch of the foot.
Phalanges: each toe has three except the great tow which has two.

72. Figure 7.55

73. Life-Span Changes
Calcium levels fall through life and the skeleton loses strength.
Osteoclasts outnumber osteoblasts.

74. Life-Span Changes
By age 35, everyone loses bone mass. Women lose bone mass faster between menopause and age seventy.
Trabecular bone is lost before compact bone.