1. Locus ceruleus volume changes are a promising biomarker for detecting Alzheimer's disease progression in pre-symptomatic stages 
Panos Theofilas, Sara Dunlop, Alexander J. Ehrenberg, Ana T. Alho, Austin Nguy, Renata Elaine Paraizo Leite, Roberta Diehl Rodriguez, Maria B. Mejia, Claudia K. Suemoto, Jose M. Farfel, Renata Eloah de Lucena Ferretti-Rebustini, Livia Polichiso, Thamiris V.G. Prata, Camila F. Nascimento, William W. Seeley, Ricardo Nitrini, Carlos Augusto Pasquallucci, Wilson Jacob-Filho, Udo Rueb, John Neuhaus, Helmut Heinsen, Lea T. Grinberg 
Alzheimer's & Dementia: The Journal of the Alzheimer's Association 
Volume 11, Issue 7, Pages P269-P271 (July 2015)
DOI: /j.jalz
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2. Figure 1
Three-dimensional reconstruction of the aminergic nucleus locus ceruleus (LC) from a case of early Alzheimer's disease (AD; Braak Braak stage II). The reconstruction was obtained from serial sections of the human brainstem using advanced graphics computing. LC (green) is located in the upper pons of the human brainstem (gray), lateral to the 4th ventricle. Even though the LC is narrow in the antero-posterior axis, it extends approximately 11 mm along the brainstem's pontine tegmentum, in tube-like shape. Therefore, pathological changes in the LC can only better appreciated on a three-dimensional reconstructions.
Alzheimer's & Dementia: The Journal of the Alzheimer's Association  , P269-P271DOI: ( /j.jalz )
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3. Figure 2
Total volume estimates of the locus ceruleus (LC) in individuals across the seven Braak and Braak (BB) stages. LC volume measurements were quantified unilaterally using the planimetry method that is based on the Cavalieri principle in a total of 58 brainstems. Our findings indicate a strong correlation between reduced LC volume and increasing BB (rho= p=0.001) that translates to a dramatic loss of total LC volume of about 8% per stage increment.
Alzheimer's & Dementia: The Journal of the Alzheimer's Association  , P269-P271DOI: ( /j.jalz )
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