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Med Chem Tutoring for Antidepressants
By Alaina Darby
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Which of the following does not inhibit DAT but inhibits both NET and SERT?
SNRIs SSRIs NSRIs DNRIs C
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Which of the following selectively inhibits NET with no significant affinity to SERT or DAT?
SNRIs SSRIs NSRIs DNRIs A
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Which of the following inhibits dopamine and norepinephrine reuptake but has little effect on serotonin? SNRIs SSRIs NSRIs DNRIs D
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Which of the following has high selectivity and affinity for SERT with low affinity for neuroreceptors or fast sodium channels? SNRIs SSRIs NSRIs DNRIs B
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Which of the following are tertiary TCA amines?
SNRIs SSRIs NSRIs DNRIs C
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Which of the following are secondary TCA amines?
SNRIs SSRIs NSRIs DNRIs A
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Which of the following is also an atypical antipsychotic?
Protriptyline Nortriptyline Amoxapine Desipramine C
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Which of the following is not true of tricyclic structures?
Can be a ring system Associated with affinity to particular receptors Restricts motility of the two phenyl rings Can be a ring system B
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Which of the following is the active metabolite of a NSRI?
Loxapine Imipramine Amitriptyline Amoxapine D
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Which of the following blocks D2 receptors?
Loxapine Imipramine Amitriptyline Amoxapine D
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Which of the following has the highest affinity and selectivity for NET among the secondary TCAs?
Amoxapine Protriptyline Maprotiline Nortriptyline C Also referred to as a tetracyclic antidepressant
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Which is not true of the sar for TCAs?
Usually substituted benzene rings C-3 ring substituent on the benzene ring generally has little effect on antidepressant activity A Cl substitution at C-3 makes it more selective for serotonin uptake The central ring reduces conformational flexibility of the phenyl rings A
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Which is true of the sar for TCAs concerning the side chains?
The side chain is never involved in a ring system Branching increases potency for transporter inhibition Usually consists of three carbon atoms separating the nitrogen and tricyclic rings Branching decreases selectivity against serotonin uptake C
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Remember Primary: not active Secondary: NET selective Tertiary: NET and SERT C
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Which of the following is not a receptor that is blocked by TCAs?
Muscarinic Alpha 1 H1 GABA Fast sodium channels All of the above are blocked D
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Which of the following is not an advantage of SSRI vs TCA?
Lower side chance of cardiotoxicity Fewer side effects Lower chance of suicide Better tolerated C
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For which of the following is the S-isomer about 100x more selective than the r-isomer?
Paroxetine Fluoxetine Citalopram Sertraline B Citalopram S-isomer is 27x more potent
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Which of the following is primarily metabolized by CYP2D6 and acts to inhibit it?
Paroxetine Fluoxetine Citalopram Sertraline A Sertraline just inhibits it
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Which of the following has two chiral centers?
Paroxetine Fluvoxamine Citalopram Sertraline D
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Which of the following has lower drug concentrations in smokers?
Paroxetine Fluvoxamine Citalopram Sertraline B Metabolized by 1A2
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Which of the following is considered to be the most powerful antidepressant made to date?
Clomipramine Amitriptyline Trimipramine Doxepin A
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Which of the following is the z-isomer more potent for sert?
Clomipramine Amitriptyline Trimipramine Doxepin D
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Which of the following is a phenylpiperazone derivative that can cause sedation due to h1R blockade?
Trazadone Aripiprazole Vilazodone Mirtazapine A
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Which of the following is used in conjunction with lithium for bipolar disorder?
Trazadone Aripiprazole Vilazodone Mirtazapine B
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Which of the following is usually classified as a NaSSA?
Trazadone Aripiprazole Vilazodone Mirtazapine D
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