1. Translating regenerative medicine to the clinic
Alicia El Haj
Director ISTM / Chair in Regenerative Medicine

2. Stem Cell therapy at Keele
Professor James Richardson
Orthopaedic Trials
Cartilage - ACI
chondrocytes – MRC - ACTIVE TRIAL
chondrocytes/MSC- ARUK/MRC ASCOT TRIA
Non Unions fractures
BM Mesenchymal stem cells (MSC)
Stroke Trials
Athersys – MSC IV
Lab built with charity money
2 GMP cell therapy laboratory
>500 patients with ACT
founded 2000
Royal Stoke Hospital Oswestry RJAH Orthopaedic Hospital 2

3. Establishing the Cell Therapy Pipeline
Bioreactor
growth
environments
Delivery systems and scaffolds
Targeting, activation and tracking

4. Arthritis Research UK Centre for Tissue Engineering
Medical Research Council UKRMP Hub in Stem cell niche
MRC UKRMP Hub in Acellular Delivery
Engineering and Physical Sciences Research Council Centre for Innovative Manufacturing in Regenerative Medicine
Biotechnology and Bioscience Research Council LOLA scheme
Nottingham, Loughborough, Liverpool, Edinburgh, Imperial, Kings, Manchester. Southampton, York, Cambridge, Aberdeen, Newcastle, UCL