1. ANTI ADRENERGIC DRUGS ANTI ADRENERGIC DRUG-
. ACTION PRODUCED BY THIS DRUG ARE TOTALLY OPPOSITE TO ADRENALINE OR ADRENERGIC DRUG.
ADRENERGIC DRUG CAN BLOCK IN FOLLOWING WAYS:
. DRUG CAUSING DEPLETION OF CATECHOLAMINES FROM VARIOUS BODY TISSUE Eg- RESERPINE.
. DRUG WHICH INTERFERE WITH THE SYNTHESIS IN ADRENERGIC NERVE OR ADRENALINE GLAND. Eg- METHYL DOPA.
. DRUG WHICH INTERFERE WITH TRANSMISSION OF IMPULSE ACROSS POST GANGLIONIC NEURON. Eg- GUANETHIDINE.
. DRUGS BLOCKING ALPHA OR BETA RECEPTOR BOTH.

2. CATECHOLAMINES DEPLETORS
. RESERPINE SHOWS ITS EFFECT BY PREVENTING THE REPEATED OF ADRENALINE OR NOR ADRENALINE CAUSING ITS DEPLETION.
. THEREFORE IT CAUSE USE IN HYPERTENSION AND PSYCHATRICS.
. HOWEVER DUE TO DEPLETION OF CATECHOLAMINES RESERPINE MAY CAUSE DEPRESSION LEADING TO SUICIDAL TENDANCY THEREFORE IT IS NO LONGER USE IN HYPERTENSION.

3. ALPHA METHYL DOPA
. It prevent synthesis of nor adrenaline by entering the neurone instead of nor adrenaline being form alpha methyl
. Nor adrenaline is formed which is inactive

4. ALPHA AND BETA BLOCKERS
1 ) ALPHA BLOCKERS :
Alpha blockers block the alpha receptor .
They are classified into –
A)Beta haloalkyl amines – eg. Phenoxybenzamine
B) Natural and dihydrogenated ergot alkaloids - eg . ERGOTOXIN
C) Imidazole derivatives – eg. Tolazoline
D) miscellaneous - eg . dibenzazepine
2 ) BETA BLOCKERS :
They blocks beta receptors and are classified into -
A) specific beta blockers - eg. Timolal
B) Beta blockers with membrane stablizing activity – eg. Propranalol
C) Beta blockers with membrane stablizing activity and inrinsic sympathomimatic activity - eg. Dichloroisoprenalin
D) Beta blocker with additional alpha blocking activity – eg . Lebetalol

5. USES OF ALPHA & BETA BLOCKERS
A ) ALPHA BLOCKER –
1 . Pentolamine is use in the treatment of pheochromocytoma
2 . tolazoline is use in the treatment of peripheral vascular diseases such as raynaud’s disease
3 . ergotamine is used in the treatment of migraine
B ) BETA BLOCKERS –
1. Hypertention
2 . angina pectories
3 . cardiac arrhythmia
4 . pheochromocytoma

6. ANTI ADRENALGIC DRUGS CREATED BY : GUIDENCE BY : SHAIKH AKIL
SHAIKH SHAKEEL
SHAIKH AAQUIB
SHAIKH AADIL
SHAIKH MUHAMMAD
GUIDENCE BY :
MS. SYEDA SHAHANA