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Table 4 Results of 3 pairwise comparisons of expanded virus groups, by use of least-squares means differences and the Tukey honestly significant difference.

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Presentation on theme: "Table 4 Results of 3 pairwise comparisons of expanded virus groups, by use of least-squares means differences and the Tukey honestly significant difference."— Presentation transcript:

1 Table 4 Results of 3 pairwise comparisons of expanded virus groups, by use of least-squares means differences and the Tukey honestly significant difference test From: The Rat-Based Neurovirulence Safety Test for the Assessment of Mumps Virus Neurovirulence in Humans: An International Collaborative Study J Infect Dis. 2005;191(7): doi: /428098 J Infect Dis | © 2005 by the Infectious Diseases Society of America

2 Table 3 Results of 3 pairwise comparisons of conservative virus groups, by use of least-squares means differences and the Tukey honestly significant difference test From: The Rat-Based Neurovirulence Safety Test for the Assessment of Mumps Virus Neurovirulence in Humans: An International Collaborative Study J Infect Dis. 2005;191(7): doi: /428098 J Infect Dis | © 2005 by the Infectious Diseases Society of America

3 Figure 3 Representative sagittal cross-sections of brains from rats inoculated with attenuated mumps vaccine virus (Jeryl Lynn, left), partially attenuated mumps vaccine virus (Urabe-AM9, middle), and wild-type mumps virus strains (88–1961, right). Arrows enlarged lateral ventricles From: The Rat-Based Neurovirulence Safety Test for the Assessment of Mumps Virus Neurovirulence in Humans: An International Collaborative Study J Infect Dis. 2005;191(7): doi: /428098 J Infect Dis | © 2005 by the Infectious Diseases Society of America

4 Figure 2 Arcsin-transformed mean neurovirulence scores, as determined for each virus strain at each laboratory. FDA, Food and Drug Administration; NIBSC, National Institute for Biological Standards and Control From: The Rat-Based Neurovirulence Safety Test for the Assessment of Mumps Virus Neurovirulence in Humans: An International Collaborative Study J Infect Dis. 2005;191(7): doi: /428098 J Infect Dis | © 2005 by the Infectious Diseases Society of America

5 Figure 1 Determination of neurovirulence score by use of a sagittal cross-section of the left hemisphere of a rat brain From: The Rat-Based Neurovirulence Safety Test for the Assessment of Mumps Virus Neurovirulence in Humans: An International Collaborative Study J Infect Dis. 2005;191(7): doi: /428098 J Infect Dis | © 2005 by the Infectious Diseases Society of America

6 Table 2 Virus titers determined by each laboratory
From: The Rat-Based Neurovirulence Safety Test for the Assessment of Mumps Virus Neurovirulence in Humans: An International Collaborative Study J Infect Dis. 2005;191(7): doi: /428098 J Infect Dis | © 2005 by the Infectious Diseases Society of America

7 Table 1 Mump virus strains used
From: The Rat-Based Neurovirulence Safety Test for the Assessment of Mumps Virus Neurovirulence in Humans: An International Collaborative Study J Infect Dis. 2005;191(7): doi: /428098 J Infect Dis | © 2005 by the Infectious Diseases Society of America

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