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Volume 108, Issue 5, Pages 1425-1433 (November 1995)
Neutrophilic Respiratory Tract Inflammation and Peripheral Blood Neutrophilia After Grain Sorghum Dust Extract Challenge Susanna G. Von Essen, MD, Dennis P. O'Neill, MS, Sandra McGranaghan, RPFT, Stephen A. Olenchock, PhD, Stephen I. Rennard, MD CHEST Volume 108, Issue 5, Pages (November 1995) DOI: /chest Copyright © 1995 The American College of Chest Physicians Terms and Conditions
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FIGURE 1 Bronchial neutrophils after inhalation challenge. Both group 1 and group 2, seen in panel A (top), had elevations in percent bronchial neutrophils above the levels seen in those challenged with HBSS (p<0.01). A similar relationship was seen in the absolute bronchial neutrophils, shown in panel B (bottom). Neither the percent nor the absolute bronchial neutrophils in group 3 were greater than in control subjects. CHEST , DOI: ( /chest ) Copyright © 1995 The American College of Chest Physicians Terms and Conditions
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FIGURE 2 Alveolar neutrophils in subjects challenged by inhalation of GSDE±corticosteroids or HBSS. As shown in panel A (top), the percent alveolar neutrophils for both groups 1 and 2 were significantly higher than for the group that received only HBSS (p values for both comparisons, <0.01). Panel B (bottom) shows absolute alveolar neutrophils, which again were significantly greater in both groups challenged with GSDE (p values <0.01 and 0.05, respectively). CHEST , DOI: ( /chest ) Copyright © 1995 The American College of Chest Physicians Terms and Conditions
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FIGURE 3 Absolute peripheral blood neutrophils after challenge with GSDE±corticosteroid or HBSS. The absolute numbers of neutrophils were significantly elevated in groups 1 and 2 compared with group 3 at +3, +5, +7, and +9 h (p<0.001, all comparisons). At +5, +7, and +9 h, those who received corticosteroid with the GSDE had significantly more WBCs and PMNs than those who received GSDE alone (p<0.01, all comparisons). CHEST , DOI: ( /chest ) Copyright © 1995 The American College of Chest Physicians Terms and Conditions
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FIGURE 4 Peripheral blood neutrophil chemotaxis of study subjects to GSDE at baseline, +7 h, and +24 h. The increase in chemotaxis to GSDE was significantly greater in group 1 than in 3 group at +7 h (p<0.001). Also, the increase in group 1 was significantly higher than in group 2, suggesting that corticosteroid decreased the response (p<0.01). CHEST , DOI: ( /chest ) Copyright © 1995 The American College of Chest Physicians Terms and Conditions
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