1. Welcome to my presentation on ICDDR,B & incepta

2. ICDDR,B
ICDDR,B stands for INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESERCH, BANGLADESH
It is an international health research institution located in Dhaka, the capital of Bangladesh.
The centre was established in 1960 as the Cholera Research Laboratory (CRL)
The CRL was internationalized and became ICDDR,B in 1978.

3. VISION
All people, especially the poor, can become healthier and can reach their full potential through the application of new knowledge. Mission To develop and promote realistic solutions to the major health, population and nutrition problems facing the poor people of Bangladesh and other settings.  

4. ICDDR,B Organogram
Although ICDDR,B has six divisions our attention mainly goes to laboratory science division

5. Laboratory Science Division Organogram
Our visited research and service labs are immunology,parasitology,virology,emtric microbiology,animal resource,nutritional biochemistry,clinical microbiology,clinical biochemistry.

6. Immunology Laboratory
Head of the department : Dr. Ferdausi Qadri
The objectives of the work carried out in this laboratory are to Strengthen and increases capabilities in rapid diagnosis of enteric pathogens using monoclonal antibodies and to contribute to understanding the immune response of diseases and compare these with responses resulting from immunization with vaccines.
Interested organisms of this lab are cholera, shigella, Typhoid, E.coli
Overall working procedures
Technique used in this lab : ELISA,ELISPOT,ALS,FACS.

7. Clinical biochemistry Laboratory
Head of the Department: Askish Kumar Chowduary
The clinical biochemistry laboratory is a very advanced Lab for analysis of specimens of blood, serum, plasma, stool, urine, cerebrospinal fluid (CSF), intra venous fluid (IVF) etc. The laboratory continued its support to Institute of Public Health (IPH) for quality control of IVF for electrolytes, glucose, and pH. The laboratory is equipped with various high-tech equipment.
Equipments are :
Electrolits analyzer
semi automatic biochemistry analyzer
automatic biochemistry analyzer
hormone analyzer
atomic absorption spectrophotometer
osmometer

8. Parasitology Lab Head: Rashidul Haque
The Parasitology Laboratory is primarily working on amoebiasis and has recently started to work on malaria and leishmaniasis. Apart from studies on Entamoeba histolytica infection, a new area of interest of the laboratory is helminthic infection and micronutrient deficiency.
The common test of this lab are :
Real time PCR
PCR
Microscopic Identification
Working Procedure :
ELISA (Antigen Detection)
Microscopy for target parasite
Sample (Stool)
------
------
Sequencing and comparing
With gene banks
------
PCR or RTPCR
------

9. Clinical Microbiology Laboratory
Head of the Department: MD. Khorshed Alam
The Clinical Microbiology Laboratory provides diagnostic support to patients of the Clinical Research and Service Centre, staff clinic, & travelers’ clinic of ICDDR, B.
Apparatus :
BacT/ALART 3D
Incubator
Media (SS agar, TTG agar, Chocolate agar, blood agar)
Working procedure:
Collection of sample ---- Autoclave the Dehydrated media ---- Incubation of the
Culture -----Colony picking Biochemical analysis  Serological analysis ---Drug resistance for treatment determination.

10. Virology Laboratory Head of the Department: Tasnim Azim
The lab is involved in studies on the viral aetiology of diarrhoea with emphasis on Group A rotavirus and is also responsible for conducting tests for HIV related to surveillance and research.
The main viruses under study:
Rota virus.
HIV virus.
Dengue virus
HCV
HBV
Influenza
Nipah
Fig : Rota virus
The common technique of this lab are:RTPCR, Fluorescence activated cell sorter, ELISA PCR,

11. Nutritional Biochemistry Laboratory
Head of the Department : M.A. Wahed
This department works on the analysis of both macro and micro nutrients
Analysis of micronutrients is performed by HPLC ,sandwich ELISA
Macro nutrient analysis is performed by
Protein – Kjeldhal Method
Total calorie determination – Bomb calorimeter
Trace element (Zn, Cu, Mg) and toxic metal (As, Cd) analysis – AAS
New methods developed in this Lab for :
a. determination of arsenic in biological samples
b. preparation of emulsifying agent using neem oil

12. Enteric microbiology laboratory
This laboratory is working in the development and application of phenotypic and molecular techniques to identify and characterize diarrhoeagenic organisms from clinical sources and the environment.
The common enteric bacteria studied in this laboratory are–
Shigella flexneri
Sulmonella
Vibrio cholera
Research or Typing:
Phenotypic characterization
Genotypic/molecular characterization
Phenotypic characterization:
1.Serotyping:
2.Anti-biogram:
3.Biochemical behavior study
Genotypic/molecular characterization:
1.Plasmid profiling:
2.PFGE (pulse field gel electrophoresis)

13. Animal Resource Branch
Head of the Department: A.S.M. Hamidur Rahman
Common laboratory animals:
Rabbit (Newzeland white).
Guinea pig (Hartly Strain).
Rat
Mouse( Swiss White.)

14. INCEPTA- The amazing tiger in the pharmaceuticals sites
Incepta pharmaceuticals is the leading pharmaceuticals established in the year 1999.
The company has a very big manufacturing factory located at Savar,35 kilometer away from Dhaka.

15. Vision of Incepta
To attain a position of leadership in pharmaceuticals.
Provide products and services of high and consistent quality ensuring value to its customer.
Attain a high level of productivity in all its operations through effective utilization of time and adoption of appropriate technology.
Contribute to the personal development, encourage employment and recognize innovation of the employees.
Growth of company.
Compete to the world market as a Bangladeshi company

16. Major Departments in the production
Technical Service
Research & Development (R&D)
Production
Quality Control
Ware House
We have visited production ,R & D and quality control (QC department)
Fig :Worker in production

17. Production Unit
Consists of two separate units in two different buildings :
1.Cephalosporine formulation unit
2.Non-Cephalosporine formulation unit

18. Production Unit Contd……..
A highly skilled team is dedicated in production with consistent quality underly cleared standard procedures (SOP). In complaints with the procedures and instruction of ISO9001 quality system.
Production facility :
Consits of six different multi storied building
Most modern pharmaceuticals production equipment imported from USA,UK,EU,Japan, Malyasia.
Especiality :
Designed room and air-conditioning systems
Personnel at the all labels undergo GMP technical training appropriate to perform their job satisfactory.

19. Schematic presentation of Production
IPC
IPC
IPC
Capsule
Tablet
IPC

20. Quality Control Department
Here maintainance is carried on four areas:
Physical control.
Chemical control.
Instrumental control.
Microbial control.
QC department is equiped with most sophisticated apparatus
Chemical control area equiped with
HPLC
GLC
AAS
FTIR
Physical control area enriched with
Stability chamber
Desolution tester
Microbiology Lab Posseses
Biohazard safety cabinet
Inhibition Zone reader
Fig : HPLC
Fig :Inhibition Zone reader

21. Research and Development
The R & D team of Incepta as pioneered the technology development and subsequent introduction of 53 new products for the first time in Bangladesh market (up to June 2004). Following are a few of this long list of products:
Losartan Potassium tablet
Pantoprazole Sodium delayed release tablet
Calcium with Vitamin C effervescent tablet
Multivitamin with multi-mineral tablet which contains 32 Vitamins & minerals.  

22. Thanks to my honorable teachers and the audience in front of me
With best regards : Md. x
Student of 4th year of Biochemistry and Molecular Biology,
University of Dhaka