1. Simulating Low-Frequency Sonic Pulsations to Achieve Thrombolysis
Thank you, pleasure to be, from weldon school of BME, start.
Joseph C Muskat
SURF 2015

2. Heart Attacks

3. Existing Approaches Clot-busting drugs
Mechanical devices (catheters, lasers)

4. Device Concept

5. Biomechanical Model for Simulating Sonic Pulsations
2D finite element model, cylindrical coordinates |||| Fewest number of nodes to maintain mechanical integrity x x

6. Validation E(numerical)= 755 Pa E(input) = 750 Pa Axial constraints
Radial constraints

7. Sonic Vibrations Produce Resonance

8. Resonance

10. Sonic Vibrations Produce Resonance
Greatest oscillation at natural frequency
Put a peak graph in top right.

11. Fracture

12. Comparison with ANSYS MATLAB deviates <2.5% Radius MATLAB ANSYS
1.3 mm
140 Hz Hz
2.0 mm
73 Hz Hz
2.5 mm
66 Hz
68.6 Hz
MATLAB deviates <2.5%

13. Conclusions
Small pressure pulsations can cause resonance in idealized blood clot models.
Clot fragmentation can occur at these resonant frequencies.
Purpose-built finite element models compare well to advanced CAD packages.

14. Future Work Atherosclerotic plaque Non-catheter, non-invasive
Distal fragmentation

15. Acknowledgements
Charles F. Babbs, MD, PhD
Matthew C. Pharris, GTA