1. From: Software applications for flux balance analysis
Figure 3: Model exchange capabilities of FBA applications. Brown-, green- and tan-coloured nodes represent the stand-alone, web-based and toolbox-based applications. Nodes with aquatic blue colour represent the software which cannot implement FBA but can help converting model format from one to another. The nodes inside rectangular represents the toolbox-based (red-coloured rectangles) or plug-in based (purple-coloured rectangles) software where the boxes denote base software and nodes inside them represent the additional libraries.
From: Software applications for flux balance analysis
Brief Bioinform. 2012;15(1): doi: /bib/bbs069
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2. From: Software applications for flux balance analysis
Figure 2: Core features of FBA software. The five core features of any FBA software include the following: (i) OS, installation and other requirements, (ii) usability, (iii) functionality, (iv) model exchange and (v) network visualization.
From: Software applications for flux balance analysis
Brief Bioinform. 2012;15(1): doi: /bib/bbs069
Brief Bioinform | © The Author Published by Oxford University Press. For Permissions, please

3. From: Software applications for flux balance analysis
Figure 1: Timeline and development of FBA software. Timeline showing the launch of FBA software tools and the milestones of key features implemented in them. Software tools are classified into any one of the three categories: stand-alone, web-based and toolbox-based. Milestones are grouped into three classes: advancements in web-technologies, supports for genome-scale model reconstruction and algorithm implementation. The vertical bars at the background denote the number of available software at the end of each year (Note: If the software has an corresponding published journal article or patent associated with them, then the date of publication is considered as the launch date of the software).
From: Software applications for flux balance analysis
Brief Bioinform. 2012;15(1): doi: /bib/bbs069
Brief Bioinform | © The Author Published by Oxford University Press. For Permissions, please

4. From: Software applications for flux balance analysis
Figure 4: Typical architecture of web application. A typical three-tier architecture of web applications that incorporates the Model-View-Controller pattern for application design.
From: Software applications for flux balance analysis
Brief Bioinform. 2012;15(1): doi: /bib/bbs069
Brief Bioinform | © The Author Published by Oxford University Press. For Permissions, please