1. Dr Philippe RONDEAUX
Chef de Clinique
RHUMATOLOGIE
ISPPC
CHU de CHARLEROI

2. Alerte Arthrose LeVif/l'Express no. 37 | 15 septembre 2017

3. Arthrose vs Arthrite

4. Arthrose vs Arthrite

5. Arthrose vs Arthrite

6. Arthrose

7. Arthrose : Prévalence

8. Arthrose

9. Arthrose : évolution

10. Arthrose : Prise en Charge

11. Arthrose : Prise en Charge

12. Sport et Arthrose

13. La Polyarthrite Rhumatoïde

14. La Polyarthrite Rhumatoïde

16. La Spondylarthrite ankylosante

17. La Spondylarthrite ankylosante

18. Physiopathologie de la Spondylarthrite ankylosante

19. Polyarthrite Psoriasique

20. Role du TNFalpha dans l’Inflamation

21. Inhibition des cytokines
Interaction normale
Neutralisation des cytokines
Cytokines inflammatoires
Anticorps monoclonal
Récepteur de cytokine
Récepteur soluble
Signaux inflammatoires
Pas de signal
Bloquage du récepteur
Anticorps
monoclonal
Inhibition of Cytokines
Cytokines exert their damaging effects by binding to specific receptors, and there are several potential approaches that can be employed to block these effects.
Cytokines can be neutralized through the use of antibodies or soluble receptors. With this approach, the cytokine never reaches the receptor on the cell of interest. This avenue for the treatment of RA has been taken with soluble TNF- receptor fusion proteins, soluble IL receptors, monoclonal antibodies against TNF-, and monoclonal antibodies against IL-6.
Receptor antagonists or antibodies can bind to cytokine receptors on cells and prevent cytokines from binding. This blocks their actions on the cell in question. This approach to the treatment of RA has been taken with recombinant IL-1Ra and an antibody against the IL-6 receptor.
Administration of anti-inflammatory cytokines can inhibit expression of inflammatory cytokines. This approach has been taken with IL-4 and IL-10.
Choy EHS, Panayi GS. Cytokine pathways and joint inflammation in rheumatoid arthritis.
N Engl J Med. 2001;344:
Antagoniste du récepteur
Pas de signal
Adapté avec la permission de Choy EHS, Panayi GS. N Engl J Med 2001;344: Copyright © 2001 Massachusetts Medical Society. All rights reserved.

22. Maladies concernées par le TNFα
Polyarthrites
Spondylarthrites
Rhumatisme Psoriasiques

23. Ostéoporose

24. Ostéoporose fracturaire

25. Ostéoporose vs Arthrose

26. Ostéoporose : diagnostique

27. Physiopathologie de l’Ostéoporose

28. Ostéoporose : traitements

30. La Fibromyalgie

33. La Fibromyalgie