1. The Burden of Diabetes

2. Worldwide Prevalence of Diabetes
Current estimated prevalence: 415 million worldwide
By 2040, 642 million people worldwide are expected to have diabetes
IDF. Diabetes Atlas Update Available at:

3. Prevalence of Diabetes and Prediabetes in the United States
9.4% of US population
Prediabetes
33.9% of US population
20081
20112
20143
20174
1. CDC. National diabetes fact sheet, CDC. National diabetes fact sheet, CDC. National diabetes statistics report, CDC. National diabetes statistics report

4. Projected Prevalence of Diabetes in the United States: 1990 to 20503 3 3 3
Year
1. National Diabetes Surveillance System CDC. National diabetes fact sheet, Boyle JP, et al. Popul Health Metr Oct 22;8:29.

5. Prevalence of Diagnosed Diabetes in Different US Ethnic and Racial Groups
US Adults ≥18 Years of Age
CDC. National diabetes statistics report,

6. Annual Incidence of Diabetes in US Children and Adolescents
US Population, 0-19 Years of Age
Race and Ethnicity
Age of Onset
Rate (per 100,000 per year)
Years
*Incidence of type 2 diabetes not reported for children 0-9 years.
API, Asians/Pacific Islanders; H, Hispanics; non-Hispanic blacks; NA, Native American; NHW, non-Hispanic whites; NHB.
Mayer-Davis EJ, et al. N Engl J Med. 2017;376:

7. T2D Prevalence Parallels Prevalence of Obesity
Obese
NHANES Data, U.S. Adults ≥20 Years1-5
Diagnosed Diabetes
CDC Data, U.S. Population6,7
Population (%)
BMI, body mass index (in kg/m2); CDC, Centers for Disease Control and Prevention; NHANES, National Health and Nutrition Examination Survey (x-axis lists last year of each survey).
*NHANES 1994 data.
1. Flegal KM, et al. Int J Obes Relat Metab Disord. 1998;22: Flegal KM, et al. JAMA ;288: Flegal KM, et al. JAMA. 2010;303: Flegal KM, et al. JAMA. 2012;307: Ogden CL, et al. JAMA. 2014;311: Harris MI, et al. Diabetes Care. 1998;21: CDC. Diabetes data & trends. Available at: and

8. Increase in Diabetes Parallels the Increase in Obesity in the United States
Population (%)
111% increase
*BMI ≥30 kg/m2.
CDC. National diabetes statistics report, Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention, Mokdad AH, et al. JAMA. 1999;282: ; Mokdad AH, et al. Diabetes Care. 2000;23: ; Flegal KM, et al. JAMA. 2016;315:

9. Diabetes Morbidity and Mortality
7th leading cause of death in US
Leading cause of blindness
Most frequent cause of kidney failure
~60% of nontraumatic lower limb amputations occur in people with diabetes
Diabetes also
Doubles the risk of periodontal disease
Doubles the risk of developing depression
Depression increases T2D risk by 60%
Increases patients’ susceptibility to acute illness (eg, pneumonia and influenza)
Worsens the prognosis of patients with acute illnesses
CDC. National diabetes statistics report, CDC. National diabetes statistics report, CDC. National diabetes fact sheet,

10. Diabetes and Morbidity and Mortality
(relative to individuals without diabetes)
CDC. National diabetes statistics report, diabetes-report-web.pdf

11. Costs of Diabetes 2012 Burden Estimate
*Includes $1.3 billion in costs from gestational diabetes.
Dall TM, et al. Diabetes Care. 2014;37:

12. Goal Achievement in Diabetes
NHANES *
N=1444
N=1342
<7
<8
>9
<70
<100
<130/80
<140/90
A1C (%)
LDL-C (mg/dL)
BP (mm/Hg)
Nonsmoker
All goals met
BP (mm/Hg)
Taking a statin
*Data from separate studies.
BP, blood pressure; LDL-C, low-density lipoprotein cholesterol; NHANES, National Health and Nutrition Examination Survey.
Ali MK, et al. N Engl J Med. 2013;368: Stark Casagrande S, et al. Diabetes Care. 2013;36:

13. A1C Achievement by Individualized Target
NHANES
(N=1444)
Age (years)
18-44
45-64
≥65
Target A1C (%)
≤6.5
≤7.0
≤7.5
≤8.0
Without complications
With complications
NHANES, National Health and Nutrition Examination Survey.
Ali MK, et al. N Engl J Med. 2013;368: