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RenaGel®, a nonabsorbed calcium- and aluminum-free phosphate binder, lowers serum phosphorus and parathyroid hormone  Eduardo A. Slatopolsky, Steven K.

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Presentation on theme: "RenaGel®, a nonabsorbed calcium- and aluminum-free phosphate binder, lowers serum phosphorus and parathyroid hormone  Eduardo A. Slatopolsky, Steven K."— Presentation transcript:

1 RenaGel®, a nonabsorbed calcium- and aluminum-free phosphate binder, lowers serum phosphorus and parathyroid hormone  Eduardo A. Slatopolsky, Steven K. Burke, Maureen A. Dillon  Kidney International  Volume 55, Issue 1, Pages (January 1999) DOI: /j x Copyright © 1999 International Society of Nephrology Terms and Conditions

2 Figure 1 Structure of RenaGel®, cross-linked poly(allylamine hydrochloride). Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

3 Figure 2 Effect of RenaGel® on serum phosphorus. During the treatment period with RenaGel the decrease in serum phosphorus 9.1 ± 2.4 to 6.6 ± 1.9 mg/dl was statistically significant (P ). Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

4 Figure 3 Effect of RenaGel® on serum calcium.
Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

5 Figure 4 Effect of RenaGel® on Ca × P product.
Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

6 Figure 5 Effect of RenaGel® on serum parathyroid hormone (PTH). At the end of the 2 week treatment, the decrease in PTH was statistically significant (P < ). After RenaGel was discontinued there was a significant increase in the levels of serum PTH (P < ). Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

7 Figure 6 Effect of RenaGel® on serum total cholesterol.
Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

8 Figure 7 Effect of RenaGel® on serum low density lipoprotein (LDL). The decrease in LDL was highly statistically significant (P < ). Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions


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