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Opioid Concentrations in Oral Fluid and Plasma in Cancer Patients With Pain  Tarja Heiskanen, MD, PhD, Kaarina Langel, MSc, Teemu Gunnar, BSc, MSc, Pirjo.

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Presentation on theme: "Opioid Concentrations in Oral Fluid and Plasma in Cancer Patients With Pain  Tarja Heiskanen, MD, PhD, Kaarina Langel, MSc, Teemu Gunnar, BSc, MSc, Pirjo."— Presentation transcript:

1 Opioid Concentrations in Oral Fluid and Plasma in Cancer Patients With Pain 
Tarja Heiskanen, MD, PhD, Kaarina Langel, MSc, Teemu Gunnar, BSc, MSc, Pirjo Lillsunde, PhD, Eija A. Kalso, MD, DMedSci  Journal of Pain and Symptom Management  Volume 50, Issue 4, Pages (October 2015) DOI: /j.jpainsymman Copyright © 2015 American Academy of Hospice and Palliative Medicine Terms and Conditions

2 Fig. 1 Flowchart. OF = oral fluid.
Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2015 American Academy of Hospice and Palliative Medicine Terms and Conditions

3 Fig. 2 Variations of opioid doses and plasma opioid concentrations. *Denotes the furthest outlying single measurement values in relation to the mean value of 5 measurements in a patient. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2015 American Academy of Hospice and Palliative Medicine Terms and Conditions

4 Fig. 3 Correlations of oral fluid and plasma opioid concentrations.
Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2015 American Academy of Hospice and Palliative Medicine Terms and Conditions

5 Fig. 4 Inter- and intrapatient variation in oral fluid and plasma opioid concentration ratios in patients (N = 29) who gave all five oral fluid and plasma samples over different time points. OF/P = oral fluid/plasma. *Denotes the furthest outlying single measurement values in relation to the mean value of 5 measurements in a patient. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2015 American Academy of Hospice and Palliative Medicine Terms and Conditions


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