1. ض م أ في المغرب PID in Morocco : When an NGO takes a country and a…continent احمد عزيز بوصفيحة Ahmed Aziz Bousfiha. aazz63@gmail.com Clinical Immunology Unit. aazz63@gmail.com Department of Pediatric Infectious Diseases. CHU Ibn Rushd. Casablanca. Morocco. Association Hajar www.hajar-maroc.org Moroccan Society for Immunodeficiencies. www.pid-moroccansociety.org www.pid-moroccansociety.org African Society for Immunodeficiencies ASID www.asid.mawww.asid.ma

2. Objectives Particularities of PID in Morocco How to succeed a Center in a limited resources country ?

3. Epidemiology PID are unrecognized in Morocco : –PIDs expected in 10 years: 2000 patients 650,000 births per year PID expected per year : 1 / 2000 Births 300 / year –But at 2010 : only 10% diagnosed = 290 HIV infection is less common –1997 - 2009: –PIDs: 225 –HIV infections: 150 Consanguinity: 20%

4. Ibtihal Benhsaein and Fatima Ailal

5. Particularities of PID in Morocco

9. The 752delG26 mutation in the RFXANK gene associated with major histocompatibility complex class II deficiency: evidence for a founder effect in the Moroccan population. Naamane H, El Maataoui O, Ailal F, Barakat A, Bennani S, Najib J, Hassar M, Saile R, Bousfiha AA. Eur J Pediatr. 2010 Apr 23.

10. Hajar, 15 mois, Consanguinité +, Cas similaires, DICS T-B+ NK – : Déficit en Jak 3 ?

12. Khaoula, 13 mois, lymphopénie. DICS T- B+ NK+ IL7Rα BMT in Span, 2002 … et celui qui la fait revivre, cest comme sil avait fait revivre lhumanité entière. Le Coran : Le festin, verset 32

13. Ayoub, SCID T-B-NK + RAG1 1st Baby grafted in Morocco,2010 Thanks to the technical assistance of our Saudis brothers : Saleh and Hamoud. Thanks to Saudi Arabia. Congratulation for Arab cooperation!

14. Saleh AL Muhsen Hamoud Al Moussa SAOUDI EXPERTS AT CASABLANCA: 2008, 2009, 2010,...

15. JL Casanova, Parrain and ASID Cofounder. Casablanca 2008

18. JMF, Dream MackersNew York, 2009

19. - Recommendations For : - GPs - Students

21. Functional Classification of the 2007 Update

23. How to succeed a PID Center in a limited resources country ?

24. F and R : disponibles Formation et Recherche : non disponibles Soins disponibles Diagnostic et Traitement : non disponibles

25. F and R : disponibles Morocco: Country with Limited Resources Formation et Recherche : non disponibles Soins disponibles

26. Diagnostic et Traitement : non disponibles F and R : disponibles Morocco: Country with Limited Resources Hajar Association Formation et Recherche : non disponibles Soins disponibles Morocco : People with illimited Generosity

27. Diagnostic et Traitement : non disponibles F and R : disponibles Morocco: Country with Limited Resources JL Casanova Formation et Recherche : non disponibles Soins disponibles Parrain with illimited Generosity Morocco : People with illimited Generosity Hajar Association

28. Diagnostic et Traitement : non disponibles F and R : disponibles Morocco: Country with Limited Resources Hajar JL Casanova Formation et Recherche : non disponibles Soins disponibles Royaume dArabie Saoudite Tunisie Contribution in developping PID in Africa In Arab Region In the World JMFIPOPI France Parrain with illimited Generosity Morocco : People with illimited Generosity

30. 1997 Necker 2000 Hajar Flux Cytometer 2007 IgIV 100% Clin Immunol Unit 1st Allograft 2008 ASID 2009 Benhsaein au KFH 1998 Labo Immu

33. Honestly, it is not only the dynamism and the organization. Allah helps sincere wishes.