1. Therapeutics 3: Antibiotics Tutoring
By Alaina Darby

2. General Principles
Morton’s Section

3. Which of the following antibiotics would be most likely to target g(-) bacteria?
Small, nonpolar, lipophilic
Large, nonpolar, lipophilic
Small, polar, hydrophilic
Large, polar, hydrophilic a

4. Jh has colitis. Which of the following is the most likely cause?
S. aureus
S. pneumoniae
E. coli
B. fragillis c

5. Which of the following would be least helpful for determining the causative bacteria?
Culture of blood
Culture of sputum
Culture of CSF
Culture of biopsied tissue b

6. Which of the following would most likely be considered bactericidal?
Kills 98% of bacteria within 12 hours
Kills 98% of bacteria within 24 hours
Kills 99.9% of bacteria within 36 hours
Kills 99.9% of bacteria within 48 hours a

7. Which of the following is a qualitative way to measure susceptibility?
Broth dilution
Kirby-Baur test
Microtubule
E-test b

8. For which of the following are concentrations regularly taken?
Penicillin
Azithromycin
Zosyn
Vancomycin d

9. Which of the following would most likely be susceptible?
MIC 8, KB 5
MIC 8, KB 20
MIC 2, KB 5
MIC 2, KB 20 d

10. If the MIC of the organism is 3, which of the following antibiotics would work best?
Peak of 2
Peak of 4
Peak of 6
Need more info d

11. If the MIC of the organism is 3, which of the following antibiotics would work best?
Peak of 4, time above MIC is 9 hours, concentration dependent
Peak of 6, time above MIC is 9 hours, concentration dependent
Peak of 8, time above MIC is 5 hours, time dependent
Need more info d

12. Ceftazidime is typically dosed 1g iv q8h
Ceftazidime is typically dosed 1g iv q8h. If susceptibility comes back as “s-dd” how might it be dosed to be effective?
0.5g IV Q4H
1g IV Q4H
1g IV Q8H
2g IV Q8H d

13. Given the following, determine how you would treat the patient.
Drug
MIC
SUSC
Tetracycline
>4 R
TMP/SMX
<10 S
Vancomycin
<1
Oxacillin 2 I
IV Tetracycline at a high dose
IV TMP/SMX at a normal dose + AMG
IV Vancomycin at a high dose
IV Nafcillin at a normal dose + AMG d

14. Which of the following is a static drug that works at the ribosome?
TMP/SMX
Gentamicin
Erythromycin
Rifampin c

15. JK has a MRSA infection. Why should he not be treated with dicloxacillin?
He needs an IV option
Resistance to dicoxacillin
He needs a cidal agent
He needs G(-) coverage b

16. JK has a MRSA infection. Why should he not be treated with dicloxacillin?
Altered porin channel
Efflux pump
Absolute change in target
Beta lactamase production c

17. RA (5 yo) has a respiratory infection that he picked up in daycare
RA (5 yo) has a respiratory infection that he picked up in daycare. Which should he be given?
Penicillin
Amoxicillin
Augmentin
Zosyn c

18. RA (5 yo) is a st. jude patient that has a respiratory infection
RA (5 yo) is a st. jude patient that has a respiratory infection. Which should he be given?
Penicillin
Amoxicillin
Augmentin
Zosyn d

19. RJ is to be given a CIVI of an antibiotic
RJ is to be given a CIVI of an antibiotic. Which of the following is most likely?
Zosyn
Gentamicin
Levofloxacin
Azithromycin a

20. Which of the following is a case in which you might give a static and cidal agent together?TB
CAP
GNR
HIV b

21. TJ has recently had surgery to transplant a lung due to lung cancer
TJ has recently had surgery to transplant a lung due to lung cancer. He is a past smoker. During the surgery, he was intubated. He was also given anti-rejection drugs before and after the transplant. Which compromised his cellular immune function?
Surgery
Intubation
Immunosuppressive drugs
Smoking a

22. Which of the following would be considered SIRS?
Oral temp 39 C, HR 85, WBC 10,000
Oral temp 37 C, HR 95, WBC 10,000
Oral temp 39 C, HR 85, WBC 2,000
Oral temp 37 C, HR 85, WBC 2,000 c

23. Which of the following would require the longest course of treatment?
Endocarditis
S. epidermitis bacteremia
E. coli bacteremia
Surgical prophylaxis a