1. Progress and Plans

2. Welcome to iPRD IC Members and prospective member Johnson-Matthey
Agenda
Introductory Presentation by Prof. Frans Muller 09:30
Discussion of HEIF5 Funding by Prof. Steve Marsden 10:00
Discussion of Doctoral Training Centre by Prof. Chris Rayner 10:30
Coffee 11:00 and “Post-It Ideas for Afternoon Discussion”
Project presentations 11:20-12:30
Dr Felix Roessler - Heterogeneous Catalysis
Prof. Philip Kocienski - Organoselenium Processes
Prof. Kevin Roberts, Dr Bob Docherty - Synthonic Engineering
Student Poster Session 12:15 and Lunch to 13:30 
New Project Discussion Groups and iPRD R+D Themes 13:30-15:50
AOB and discussion 15:50-16:00

3. Now iPRD is operating effectively need to ensure sustainability
iPRD Sustainability
Now iPRD is operating effectively need to ensure sustainability
iPRD
ERDF
YF Grant
Transformation Fund
HEIF5
Project grants
Contract work
Industrial Club
Prof. Muller
+ 2 Fellows
Business development manager
Dr Hayley Jackson
Could terminate Sept 2012
Staff Costs
Overheads
Equipment + Maintenance Consumables

4. Project Grants EPSRC Innovative Manufacture Centre
- Failed 2010 application in integrated primary and secondary manufacture
2011 call. Any industrial interest? What areas (not the same)? Use this afternoon session to define?
Innovative Medicines Initiative looking at green (bio)synthesis methods
Outline application made. EU10m over 4 yrs. Consortium partners: 13 including iPRD, CoEBio3, York, Durham, Rostock, Antwerp, ACIB, Stuttgart, CatSci, Reaxa….
EU FP7 outline proposal being made to Precision Manufacture of Nanoparticles (Limerick leading iPRD as partner)
Missed TSB ICT Call (Predictive Solubility project) however new TSB call in high value manufacture for Q Any member interest? Use this afternoon session to define?

5. Traffic Light View on Internal/External Partners and Funding
UoL technology partners
External funding/collaborative partners
NMi
Astbury
Technology
Strategy
Board
EPSRC EU
Polymer
IRC
Particle
CiC
Healthcare
BHRC
Chemistry
Innovation
KTN
Yorkshire
Forward
iPRD
CPI
(Wilton)
IPI
(Bradford)?
BRITEST?
CoEBio3
(M’cr)
IPOS
(H’field)
Industrial Club
(ca. 15 companies)
Strathclyde?
CPACT?
UCL Biotech?
External technology partners

6. Equipment : Flow Hydrogenation
Now have a Parr 2-stage CSTR flow hydrogenator
Multi- gas/liquid capability eg H2 and CO
2*80ml stirred cascade pots capable of kg product
Up to 70bar operating pressure
Substrate and gas flow controlled interface
Pink = PFR
Green+Pink = 2 CSTR’s
Red box = 1 CSTR

7. Student Project Work MSc Summer Projects - Completed (10 week)
Hydrogen borrowing (racemic alcohol to homochiral amine)
CIDT green process to (R) or (S)-2-chloropropionic acid
Removing amine contamination from solid NaCl waste stream
Flow electrochemical reduction of benzaldehyde
Scale-Up aspects of natural product extraction and purification
DTC Projects (Just Starting – 6 month)
Slow flow hetereogeneous (NiEnCat) catalytic hydrogenation of nitriles
Dispersion measurement and modelling – in-line UV measurement
Formation of intra-particulate reagents – encapsulated solid reagents
MChem / MEng projects (1 year part-time)
Build variable residence time unit using jacketed static mixers
Build continuous liquid-liquid extraction unit for litre-scale operation
Distillation scale-up – measure effect of cold spots
Properties of weak solid networks – preventing clogging!

8. Green process to (R) or (S)-2-chloropropionic acid
(S)-2-CPA = 1000’s tpa
Current processes all involve resolution
Target solvent-free, no waste process
Achieved in 10 week project:
outline “engineered” CIDT process
20% de solvent free
salt break by steam distillation
racemisation with NaCl and 18[C]6 solvent free

9. Dynamic catalyst system
Aim to test dynamic catalyst system:
one-pot catalytic dehydrogenation and asymmetric reduction by hydrogen borrowing
Achieved in 10 week project:
telescoped process
Reaction rates for each step determined with chiral and achiral catalyst