1. Use of the genomic matching technique to complement multiplex STR profiling reduces DNA profiling costs in high volume crimes and intelligence led screens 
R. Laird, R.L. Dawkins, S. Gaudieri 
Forensic Science International 
Volume 151, Issue 2, Pages (July 2005)
DOI: /j.forsciint
Copyright © 2005 Elsevier Ireland Ltd Terms and Conditions

2. Fig. 1
Map of the human MHC for indicating the locations of the polymorphic genomic blocks. Adapted from Dawkins et al. [3], and the MHC Map ( (not all genes are shown). Genomic blocks are shaded. The beta-block spans approximately 300kb and includes HLA-B and -C. The GMT primers for the beta-block are located within duplicated segments containing the MICA and MICB genes. A third beta-block priming site is located telomeric of HLA-C [4].
Forensic Science International  , DOI: ( /j.forsciint )
Copyright © 2005 Elsevier Ireland Ltd Terms and Conditions

3. Fig. 2
Examples of matched and mismatched profiles generated with the GMT. (A) GMT profiles from two samples with the same beta-block are aligned using the ABI 310 genetic analyser. The profiles show perfect alignment including the smallest intensity bands. The vertical axis records the relative intensity of product fluorescence while the horizontal axis records the scan number (molecular weight) with the smallest products the first to pass through the capillary. (B) Example of a beta-block mismatch detected with the ABI 310 genetic analyser. The overall GMT profile pattern is clearly different for the two samples. (C) Overlay of the GMT profile for sample R851518B with the Genescan ROX-1000 molecular weight standard (black). The majority of the GMT peaks (profile information) are less than 317bp. Some heteroduplex peaks are slightly larger and may be lost in degraded samples or partial profiles. All profiles are aligned with GeneScan™. Peaks marked with asterisk (*) in the standard are not used in the sizing of products.
Forensic Science International  , DOI: ( /j.forsciint )
Copyright © 2005 Elsevier Ireland Ltd Terms and Conditions

4. Fig. 3
GMT profiles are reproducible to 390pg of DNA using the ABI 310 genetic analyser. (A) Profiles for samples 1 (100ng), 2 (25ng) and 3 (6.25ng) match for DNA sample R851518B. (B) GMT profiles for samples 1 (100ng), 2 (25ng), 3 (6.25ng), 4 (1.56ng), 5 (390pg) and 6 (9.7pg). A match is observed between sample 5 (390pg=pink) and 1 (100ng=black) with a drop-out of peaks beginning in the profile for sample 6 (blue) generated from 9.7pg of DNA. Sample 7 is the negative control. The axes as for Fig. 2.
Forensic Science International  , DOI: ( /j.forsciint )
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5. Fig. 4
Individual GMT profiles in a two part mixture (1:3) would not be excluded as contributing to the overall mixed profile. Mixed profiles were detected using the Genescan (A) Individual profiles for samples A and B were mixed using the ratio 1:3. The lesser component ‘A’ could clearly be identified as contributing to the mixed profile in a 1:3 mixture. (B) When samples A and B were mixed with a ratio 1:5 the detail of the smaller peaks from the lesser mixture component is lost in the mixed profile. The first peak in all profiles is the 59bp internal marker. The axes as for Fig. 2.
Forensic Science International  , DOI: ( /j.forsciint )
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6. Fig. 5
GMT can be used to profile and match buccal and fingerprint samples. A fingerprint and buccal sample was taken from donor (08) and extracted using the chelex method. The GMT produced a DNA profile match, as illustrated. The axes as for Fig. 2. The 59bp and 555bp internal markers are indicated. GMT profiles were run on the Genescan 2000.
Forensic Science International  , DOI: ( /j.forsciint )
Copyright © 2005 Elsevier Ireland Ltd Terms and Conditions