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Intestinal Microbiota-Dependent Phosphatidylcholine Metabolites, Diastolic Dysfunction, and Adverse Clinical Outcomes in Chronic Systolic Heart Failure 

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Presentation on theme: "Intestinal Microbiota-Dependent Phosphatidylcholine Metabolites, Diastolic Dysfunction, and Adverse Clinical Outcomes in Chronic Systolic Heart Failure "— Presentation transcript:

1 Intestinal Microbiota-Dependent Phosphatidylcholine Metabolites, Diastolic Dysfunction, and Adverse Clinical Outcomes in Chronic Systolic Heart Failure  W.H. Wilson Tang, MD, Zeneng Wang, PhD, Kevin Shrestha, MD, Allen G. Borowski, RDCS, Yuping Wu, PhD, Richard W. Troughton, MBBS, Allan L. Klein, MD, Stanley L. Hazen, MD, PhD  Journal of Cardiac Failure  Volume 21, Issue 2, Pages (February 2015) DOI: /j.cardfail Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Fig. 1 Relationship between intestinal microflora–dependent phosphatidylcholine metabolites and diastolic dysfunction in chronic systolic heart failure. TMAO, trimethylamine-N-oxide. Journal of Cardiac Failure  , 91-96DOI: ( /j.cardfail ) Copyright © 2015 Elsevier Inc. Terms and Conditions

3 Fig. 2 Kaplan-Meier survival curve stratified according to levels of trimethylamine-N-oxide (TMAO) and N-terminal pro–B-type natriuretic peptide (NT-proBNP) levels. −/+ TMAO, below versus above 6.1 μmol/L; −/+ NT-proBNP, below versus above 1,473 pg/mL (median). Journal of Cardiac Failure  , 91-96DOI: ( /j.cardfail ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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