1. Rob Corbett NCCN Christchurch
Burkitt Lymphoma
Rob Corbett
NCCN
Christchurch

2. Burkitt Lymphoma Non-Hodgkin lymphoma or Mature B cell lymphoma
Very rapid growth!
Diverse / multiofocal presentations
3 types:
Endemic
Sporadic
Immune-deficiency
Spread to BM and CNS
Very sensitive to chemotherapy
Endemic:
EBV + malaria
Found:
Tropical Africa
PNG / Solomons
30-50% of childhood cancers
6yrs >males
Sites
Abdomen
Orbit/jaw
Both
Paraspinal

3. Burkitt Lymphoma Sporadic Both Endemic and Sporadic: Found
Europe
N Amercia
Australasia
Peak age sl older
Marked male predominance
Abdominal disease, then head and neck
Both Endemic and Sporadic:
Stage I/II 20%
Stage III 65%
Stage IV 15%

4. Burkitt Lymphoma – Patient Journey
PNG
5yo male
Ill for 3 weeks with abdominal distention and wt loss
O/E
Unwell uncomfortable
Cachetic pale
Abdomen “full” and tense without discreet masses
Radiology
US – hypoechoic masses CT
Diagnosis
Fine needle aspirate
Sample fluid
“starry sky”
Staging
CSF
BMs

5. Burkitt Lymphoma – Patient Journey
Supportive care vital
Pain control
Infection
Nutrition
Tumour lysis syndrome – critical
Treatment – depends on resources

6. Patient Journey 12 month EFS Overall 61% Stage I 100% Stage II 85%
Stage III 60%
Stage IV 27%

7. Burkitt Lymphoma – Pacific Is