1. Anticonvulsants
By Alaina Darby

2. Which of the following is not a type of seizure that is generated from multiple regions on both hemispheres of the brain?
Tonic
Myoclonic
Complex partial
Absence (petit mal) c

3. GABAergic neurotransmission enhancement Screening tests
Which of the following is not a mechanism-oriented approach for epilepsy drug development?
GABAergic neurotransmission enhancement
Screening tests
Glutamate neurotransmission inhibition
Modification of ion channels b

4. Improved drug efficacy
Which would not be an application for surgical resection or vagus nerve stimulation treatment in epilepsy?
Drug resistance
Drug intolerance
Reduction of drug dose
Improved drug efficacy d

5. Discontinue the phenytoin
Stacie has developed diplopia and ataxia after taking phenytoin. What should the doctor do?
Adjust her dose down
Treat the side effects
Change her medication
Discontinue the phenytoin a

6. Amy has been experiencing absence seizures
Amy has been experiencing absence seizures. Which of the following would be best for her to take?
Carbamazepine
Phenobarbital
Clonazepam
Tiagabine c

7. Which of the following would be least likely to increase plasma concentrations of warfarin due to plasma protein binding?
Tiagabine
Phenytoin
Valproate
Carbamazepine d

8. Amanda presents to the doctor with hirsutism and gingival hypertrophy
Amanda presents to the doctor with hirsutism and gingival hypertrophy. Which of the following AED’s is she taking?
Phenytoin
Phenobarbital
Valproate
Vigabatrin a

9. Which of the following AED’s does not inhibit Na+ channels?
Lamotrigine
Topiramate
Felbamate
Zonisamide c

10. Which of the following AED’s enhances K+ channel function? Rufinamide
Felbamate
Ezogabine
Lacosamide c

11. Which of the following antagonizes glutamate receptors and can be dosed once per day?
Carbamazepine
Perampanel
Gabapentin
Felbamate b

12. Doug has partial seizures, liver failure, and is taking warfarin
Doug has partial seizures, liver failure, and is taking warfarin. Which of the following should he use?
Ethosuximide
Carbamazepine
Valproate
Phenytoin b

13. Kara is pregnant and has generalized tonic-clonic seizures
Kara is pregnant and has generalized tonic-clonic seizures. Which of the following could she take?
Valproate
Phenytoin
Topiramate
Zonisamide d

14. Samantha has started having absence seizures
Samantha has started having absence seizures. Which of the following would be the drug of choice for this type of seizure?
Ethosuximide
Valproate
Lamotrigine
Clonazepam a

15. Drew is anemic and has partial seizures
Drew is anemic and has partial seizures. Which of the following would he be able to take?
Topiramate
Carbamazepine
Felbamate
Phenobarbital a

16. Which of the following would be preferred in status epilepticus?
Diazepam
Lorazepam
Clonazepam
Clorazepate b

17. Which of the following AED’s has no effect on the GABA receptors?
Gabapentin
Felbamate
Topiramate
Phenobarbital a

18. Which of the following AED’s would not be used to treat Lennox-Gastaut syndrome?
Lamotrigine
Felbamate
Lacosamide
Rufinamide c

19. Which of the following is considered a refractory drug for partial seizures due to its side effects of vision loss, blue pigmentation in skin, and bladder dysfunction?
Vigabatrin
Ezogabine
Felbamate
Topiramate b

20. Sally has developed glaucoma
Sally has developed glaucoma. Which of the following AED’s was she probably taking?
Vigabatrin
Ezogabine
Felbamate
Topiramate d

21. Which of the following does not cause diplopia and ataxia? Phenytoin
Felbamate
Carbamazepine
Lamotrigine b

22. Which of the following is not used as an add-on therapy? Pregabalin
Perampanel
Lacosamide
Topiramate d

23. Valerie is experiencing hair loss, fine tremors, and weight gain
Valerie is experiencing hair loss, fine tremors, and weight gain. Which of the following might she be taking?
Felbamate
Valproate
Levetiracetam
Vigabatrin b

24. Which of the following AED’s is not thought to exert its effect by inhibiting glutamate release?
Lamotrigine
Gabapentin
Perampanel
Levetiracetam c

25. Which of the following AED’s does not block sodium channels? Phenytoin
Lamotrigine
Zonisamide
Vigabatrin d

26. Which of the following should not be taken with erythromycin?
Valproate
Lamotrigine
Carbamazepine
Perampanel c

27. Which of the following does not induce UGT? Phenytoin Lamotrigine
Carbamazepine
Phenobarbital b

28. Which of the following would not increase the risk of pregnancy when taken with oral contraceptives?
Tigabine
Phenytoin
Carbamazepine
Phenobarbital a

29. Which of the following does not work by increasing the levels of GABA?
Felbamate
Tagabine
Vigabatrin
Valproate a

30. Which of the following does not cause problems in the eye? Vigabatrin
Ezogabine
Zonisamide
Topimerate c