1. TPMI Research Day October 8th, 2015
Patrick McNicholas

2. Background Patrick McNicholas, B.Sc.
Graduated from Memorial University in April 2015, majoring in Biochemistry/Nutrition with a minor in German studies.
Currently a M.Sc candidate at Memorial University in the Clinical Epidemiology department.

3. Program & Project M.Sc candidate, Clinical Epidemiology
Supervising committee: Dr. Patrick Parfrey, Dr. Brendan Barrett & Dr. Elizabeth Dicks
“Health Policy for Screening in Families of Colorectal Cancer Patients”
(Owen Parfrey, Carol Negrijn)

4. Project Goals
Using data from the Newfoundland Familial CRC Registry and from the Community Clinic for Familial CRC. I will examine:
1. The efficiency, utility and costs of tumor testing for Lynch Syndrome in all CRC patients compared to tumor testing in a subset of patients at high risk of CRC.
2. The utility of a multivariate Prediction model for colonoscopy screening recommendations in non-Lynch families with CRC compared to recommendations actually made by a genetic councillor.
3. Policy options for a population based familial CRC clinic.

5. Cont’d Screening in families of CRC patients: Screening colonoscopy
Decision tree to predict screening frequency using the Amsterdam and Bethesda criteria
First degree relative(s) with multiple adenomatous polyps.
Screening for Lynch Syndrome
Family risk
Testing for mutations using tumors and DNA
Lynch Syndrome mutations

6. Thank you