1. MALIGNANT MELANOMA

2. Outline Introduction Aetiology Types Invasion and Metastasis
Risk Factors
Diagnosis and Staging
Treatment and Prevention

3. Skin: Epidermis - Melanocytes
In stratum basale
Pale “halo” of cytoplasm
Neural crest
Produce melanin and pass it on to nearby keratinocytes
Melanin covers nuclei of nearby keratinocytes
Skin colour depends on melanocytes activity, rather than the number present

4. MALIGNANT MELANOMA
A tumour arising from melanocytes of the basal layer of the epidermis
Less commonly – uveal tract (eye) and meningeal membranes

5. AETIOLOGY The cause is unknown. Excessive exposure to sunlight
Genetic predisposition

6. RISK FACTORS FOR MELANOMA
Large numbers of benign naevi
Clinically atypical naevi
Severe sunburn
Early years in a tropical climate
Family history of MM
Important to differentiate the navi from early malanoma
5% familial – genes arnd chrmosome 9p21 appears to be involved.

7. Clinical features Occur anywhere on the skin
Females (commonest is lower leg)
Males ( back).
Early melanoma is pain free. The only symptom if present is mild irritation or itch.

8. AIDS IN CLINICAL DIAGNOSIS
GLASGOW SYSTEM
Major:
Change in size
Irregular pigment
Irregular outline
Minor:
Diameter >6mm
Inflammation
Oozing/bleeding
Itch/altered sensation
AMERICAN ‘ABCDE’
SYSTEM
Asymmetry
Border
Colour
Diameter
Evolution
1 major and 1 or more minor should be considered for exicion and diagnostic biopsy.

9. Evolving; a mole or skin lesion that looks different from the rest or is changing in size, shape, or color

10. TYPES OF MELANOMA Superficial spreading Malignant melanoma
Nodular melanoma
Letingo maligna melanoma
Acral malanoma

11. SUPERFICIAL SPREADING
The most common type of MM in the white-skinned population – 70% of cases
Commonest sites – lower leg in females and back in males
In early stages may be small, then growth becomes irregular

12. NODULAR Commoner in males Trunk is a common site Rapidly growing
Usually thick with a poor prognosis
Black/brown nodule
Ulceration and bleeding are common

13. ACRAL LENTIGINOUS MELANOMA
In white-skinned population this accounts for 10% of MMs, but is the commonest MM in nonwhite-skinned nations
Found on palms and soles
Usually comprises a flat lentiginous area with an invasive nodular component

14. SUBUNGAL MELANOMA Rare
Often diagnosed late – confusion with benign subungal naevus, paronychial infections, trauma
Hutchinson’s sign – spillage of pigment onto the surrounding nailfold

15. LENTIGO MALIGNA MELANOMA
Occurs as a late development in a lentigo maligna
Mainly on the face in elderly patients
May be many years before an invasive nodule develops

16. DDx Superficial spreading melanomas Benign melanocytic naevi.
Nodular melanomas
Vascular tumor
Histiocytoma
Latingo maligna melanoma
Seborrhic keratoses

18. PROGNOSTIC VARIABLES Breslow depth 5 year survival In situ 95-100%
<1mm
1-2mm
80-96%
2.1-4mm
60-75%
>4mm
50%
The Breslow thickness is the single most important prognostic variable (distance in mm of the furthest tumour cell from the basal layer of the epidermis)

19. Scalp lesions worse prognosis, then palms and soles, then trunk, then extremeties
Younger women appear to do better than either men at any stage or women over 50
Ulceration of the tumour surface is a high risk factor

20. MANAGEMENT Surgical resection of tumour MOHS technique
Lymph node dissection
Chemotherapy
Radiotherapy
Immunotherapy

21. Prevention Reduce risk factor exposure:
Covering up (sunscreen, sunglasses, clothes)
Avoidance (less time in sun)
Screening (possibly feasible)