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De novo donor-specific HLA antibodies are associated with early and high-grade bronchiolitis obliterans syndrome and death after lung transplantation 

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Presentation on theme: "De novo donor-specific HLA antibodies are associated with early and high-grade bronchiolitis obliterans syndrome and death after lung transplantation "— Presentation transcript:

1 De novo donor-specific HLA antibodies are associated with early and high-grade bronchiolitis obliterans syndrome and death after lung transplantation  Matthew R. Morrell, MD, Joseph M. Pilewski, MD, Cynthia J. Gries, MD, Matthew R. Pipeling, MD, Maria M. Crespo, MD, Christopher R. Ensor, PharmD, Samuel A. Yousem, MD, Jonathan D’Cunha, MD, Norihisa Shigemura, MD, Christian A. Bermudez, MD, John F. McDyer, MD, Adriana Zeevi, PhD  The Journal of Heart and Lung Transplantation  Volume 33, Issue 12, Pages (December 2014) DOI: /j.healun Copyright © 2014 International Society for Heart and Lung Transplantation Terms and Conditions

2 Figure 1 (A) Freedom from BOS in patients who developed dnDSA and those who did not develop dnDSA. (B) Freedom from high-grade BOS (Stage ≥2) in those patients who developed dnDSA and those who did not develop dnDSA. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2014 International Society for Heart and Lung Transplantation Terms and Conditions

3 Figure 2 (A) Freedom from death in patients who developed dnDSA and those who did not develop DSA. (B) Freedom from death attributable to BOS in patients who developed dnDSA and those who did not develop dnDSA. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2014 International Society for Heart and Lung Transplantation Terms and Conditions

4 Figure 3 (A) Freedom from BOS in patients with Class I, Class II and Class I and II dnDSA. (B) Freedom from death in patients with Class I, Class II and Class I and II dnDSA. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © 2014 International Society for Heart and Lung Transplantation Terms and Conditions


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