1. Medical Immunology

2. microorganism attack us be able to inside us A fight a body
keep preventing the microorganisms from entry into the body and using us as host

3. immune system helping us against the microorganisms
The primary function
Immune defense

4. The first lecture
a picture of how the immune system works

5. Adaptive immune system
Innate immune system
Adaptive immune system
mechanical barrier
unknown cell
dendritic cell
IL-4
IL-4
IL-5
naïve T cell
helper T cell 2, Th2
IL-12
defensin
helper T cell 1, Th1
cytotoxic T cell
Interferon γ
IL-2
macrophage
cilia
kill
low pH

6. Two types of immune system
Innate immune system
Adaptive immune system
T cells mediated cellular immune response
B cells mediated humoral immune response

7. Innate and adaptive immune system
Act in cooperative and interdependent ways
Discuss the collaboration of these two forms of immune system.
The innate immune system initiates the adaptive immune system
The adaptive immune system enhances the activity in the innate immune system

8. Subsequent lectures immune organs Immune molecules Immune cells
MHC, immunoglobulin, complement system, etc.
Immune cells
Macrophage, dendritic cell, T cell, B cell, etc
Innate immune response
Adaptive immune response

9. The immune system is a “Two-Edged Sword”
Protection (protect the host from infectious diseases)
Damage to the host
Inappropriate reaction to “self”: autoimmune disease
Ineffective immune response: immunodeficiency
Overreactive immune response: hypersensitivity
(clinical immunology)

10. Study question The immune response includes ( ) and ( ).
A: innate immune response and adaptive immune response
Adaptive immune response includes ( ) and ( ).
A: cellular immune response and humoral immune response
The cellular immune response is mediated by ( ) cells and the humoral immune response is mediated by ( ) cells.
A: T cells and B cells

11. Study question
Innate and adaptive immunity act in cooperative and interdependent ways to protect the host. Discuss the collaboration of these two forms of immunity.