1. Elements of the Immune System and their Roles in Defense
Peter Parham
The Immune System
Fourth Edition
Chapter 1
Elements of the Immune System and their Roles in Defense
Copyright © Garland Science 2015

2. CHAPTER CONTENTS
1-1 Numerous commensal microorganisms inhabit healthy human bodies
1-2 Pathogens are infectious organisms that cause disease
1-3 The skin and mucosal surfaces form barriers against infection
1-4 The innate immune response causes inflammation at sites of infection
1-5 The adaptive immune response adds to an ongoing innate immune response
1-6 Adaptive immunity is better understood than innate immunity
1-7 Immune system cells with different functions all derive from hematopoietic stem cells

3. CHAPTER CONTENTS
1-8 Immunoglobulins and T-cell receptors are the diverse lymphocyte receptors of adaptive immunity
1-9 On encountering their specific antigen, B cells and T cells differentiate into effector cells
1-10 Antibodies bind to pathogens and cause their inactivation or destruction
1-11 Most lymphocytes are present in specialized lymphoid tissues
1-12 Adaptive immunity is initiated in secondary lymphoid tissues
1-13 The spleen provides adaptive immunity to blood infections
1-14 Most secondary lymphoid tissue is associated with the gut

4. Introduction

5. Introduction

6. Introduction

7. ELEMENTS OF THE IMMUNE SYSTEM AND THEIR ROLES IN DEFENSE
1-1 Numerous commensal microorganisms inhabit healthy human bodies

8. 1-1 Numerous commensal microorganisms inhabit healthy human bodies

9. ELEMENTS OF THE IMMUNE SYSTEM AND THEIR ROLES IN DEFENSE
1-2 Pathogens are infectious organisms that cause disease

10. 1-2 Pathogens are infectious organisms that cause disease

11. 1-2 Pathogens are infectious organisms that cause disease

12. 1-2 Pathogens are infectious organisms that cause disease

13. 1-2 Pathogens are infectious organisms that cause disease

14. 1-2 Pathogens are infectious organisms that cause disease

15. 1-2 Pathogens are infectious organisms that cause disease

16. ELEMENTS OF THE IMMUNE SYSTEM AND THEIR ROLES IN DEFENSE
1-3 The skin and mucosal surfaces form barriers against infection

17. 1-3 The skin and mucosal surfaces form barriers against infection

18. ELEMENTS OF THE IMMUNE SYSTEM AND THEIR ROLES IN DEFENSE
1-4 The innate immune response causes inflammation at sites of infection

19. 1-4 The innate immune response causes inflammation at sites of infection

20. 1-4 The innate immune response causes inflammation at sites of infection

21. ELEMENTS OF THE IMMUNE SYSTEM AND THEIR ROLES IN DEFENSE
1-5 The adaptive immune response adds to an ongoing innate immune response

22. 1-5 The adaptive immune response adds to an ongoing innate immune response

23. 1-5 The adaptive immune response adds to an ongoing innate immune response

24. ELEMENTS OF THE IMMUNE SYSTEM AND THEIR ROLES IN DEFENSE
1-6 Adaptive immunity is better understood than innate immunity

25. 1-6 Adaptive immunity is better understood than innate immunity

26. ELEMENTS OF THE IMMUNE SYSTEM AND THEIR ROLES IN DEFENSE
1-7 Immune system cells with different functions all derive from hematopoietic stem cells

27. 1-7 Immune system cells with different functions all derive from hematopoietic stem cells

28. 1-7 Immune system cells with different functions all derive from hematopoietic stem cells

29. 1-7 Immune system cells with different functions all derive from hematopoietic stem cells

30. 1-7 Immune system cells with different functions all derive from hematopoietic stem cells

31. 1-7 Immune system cells with different functions all derive from hematopoietic stem cells

32. 1-7 Immune system cells with different functions all derive from hematopoietic stem cells

33. 1-7 Immune system cells with different functions all derive from hematopoietic stem cells

34. 1-7 Immune system cells with different functions all derive from hematopoietic stem cells

35. 1-7 Immune system cells with different functions all derive from hematopoietic stem cells

36. ELEMENTS OF THE IMMUNE SYSTEM AND THEIR ROLES IN DEFENSE
1-8 Immunoglobulins and T-cell receptors are the diverse lymphocyte receptors of adaptive immunity

37. 1-8 Immunoglobulins and T-cell receptors are the diverse lymphocyte receptors of adaptive immunity

38. ELEMENTS OF THE IMMUNE SYSTEM AND THEIR ROLES IN DEFENSE
1-9 On encountering their specific antigen, B cells and T cells differentiate into effector cells

39. ELEMENTS OF THE IMMUNE SYSTEM AND THEIR ROLES IN DEFENSE
1-10 Antibodies bind to pathogens and cause their inactivation or destruction

40. 1-10 Antibodies bind to pathogens and cause their inactivation or destruction

41. ELEMENTS OF THE IMMUNE SYSTEM AND THEIR ROLES IN DEFENSE
1-11 Most lymphocytes are present in specialized lymphoid tissues

42. 1-11 Most lymphocytes are present in specialized lymphoid tissues

43. 1-11 Most lymphocytes are present in specialized lymphoid tissues

44. ELEMENTS OF THE IMMUNE SYSTEM AND THEIR ROLES IN DEFENSE
1-12 Adaptive immunity is initiated in secondary lymphoid tissues

45. 1-12 Adaptive immunity is initiated in secondary lymphoid tissues

46. 1-12 Adaptive immunity is initiated in secondary lymphoid tissues

47. 1-12 Adaptive immunity is initiated in secondary lymphoid tissues

48. 1-12 Adaptive immunity is initiated in secondary lymphoid tissues

49. 1-12 Adaptive immunity is initiated in secondary lymphoid tissues

50. ELEMENTS OF THE IMMUNE SYSTEM AND THEIR ROLES IN DEFENSE
1-13 The spleen provides adaptive immunity to blood infections

51. 1-13 The spleen provides adaptive immunity to blood infections

52. 1-13 The spleen provides adaptive immunity to blood infections

53. 1-13 The spleen provides adaptive immunity to blood infections

54. 1-13 The spleen provides adaptive immunity to blood infections

55. ELEMENTS OF THE IMMUNE SYSTEM AND THEIR ROLES IN DEFENSE
1-14 Most secondary lymphoid tissue is associated with the gut

56. 1-14 Most secondary lymphoid tissue is associated with the gut