1. Serum Creatinine Presented By Assist.Lecturer Aseel Ghassan Daoud
M.Sc. In pharmacy/ Clinical laboratory sciences

2. What is creatinine and creatinine clearance test?
This test measures the level of the waste product creatinine in blood and urine
This test provides more sensitive measure of renal damage than blood urea?
What is creatinine?
It is a non protein end product of creatine metabolism
Its amount in serum is proportional to muscle mass

3. It is easily excreted by kidneys with minimum or no tubular reabsorption
It is directly related to GFR
Its level remains normally constant
Blood creatinine level:
It shows how well the kidneys are working
It is higher in men than in women

4. Creatinine clearance test:
It measures how well creatinine is removed from the body by kidneys
It gives better information than blood creatinine test on how well the kidneys are working
It is done on both a blood or urine sample

5. Reference values: Serum Men: 0.7-1.2 mg/dl Women: 0.5-0.9 mg/dl
Clearance test
Men: ml/min
Women: ml/min

6. Pathological:
Increase:
Increased rate of formation:

7. Diminished renal excretion of creatinine:

8. Decrease:
Muscle disease such as muscle dystrophy

9. What are medicines that increase blood creatinine?
Anti hypertensives: ACE inhibitors ex: captopril
NSAIDs: ibuprofen, naproxen
Diuretics: furosemide
Antibiotics: aminoglycosides (gentamicin) and cephalosporins (cefoxitin)