1. Parameter WT
Rnd3+/- n 7
Body weight (g)
25.59±4.02
25.52±2.11
IVS;d (mm)
0.77±0.09
0.75±0.14
LVID;d (mm)
3.83±0.47
4.02±0.41
LVPW;d (mm)
0.67±0.08
0.66±0.13
IVS;s (mm)
1.13±0.06
1.17±0.16
LVID;s (mm)
2.53±0.40
2.65±0.51
LVPW;s (mm)
1.01±0.14
1.05±0.16
Stroke Volume (µl)
42.61±9.53
49.74±8.00
Ejection Fraction (%)
66.11±6.73
66.37±7.57
Fractional Shortening (%)
36.11±4.82
36.63±5.97
Cardiac Output (ml/min)
16.74±4.23
19.44±4.27
Supplementary table 1 Echocardiographic assessments of cardiac functions and cardiac morphology in Rnd3+/- and wild-type (WT) control mice under physiology conditions. No significant differences were detected between the two group of mice. d, diastolic; s, systolic; IVS, interventricular septum thickness; LVID, left ventricle inner dimension; LVPW, left ventricle posterior wall thickness. n = numbers of 10- to 15-wk-old male mice used for analysis. Statistical significance was determined by unpaired, two-tailed student’s t test. Data are means ± s.d.

2. Supplementary figure 1 Multiple comparisons of systolic and diastolic blood pressures among three groups: Sham, TAC only, and TAC plus Fasudil treatment. No significant differences were detected either between WT and Rnd3+/- mice or among the mice in three groups. Statistical significance was determined by Kruskal-Wallis One Way ANOVA on Ranks followed by Dunn’s method. Data are means ± s.d.
Sham
TAC +Fasudil
TAC
Systolic blood pressure
(mmHg) 5 6 3 4
Rnd3+/- WT
Diastolic blood pressure