1. Maintain kidney function for CKD
PROBIO-K
Complex Powder
Maintain kidney function for CKD
Copyright © New Bellus Inc. All rights reserved.

2. Chronic kidney disease
Chronic kidney disease (CKD) is a progressive loss in kidney function  over time that can lead to kidney failure, also called end-stage renal disease, ESRD, which requires dialysis or a kidney transplant to maintain life. Another consequence of CKD is that it increases the risk of cardiovascular disease.
Chronic kidney disease
ESRD

3. Dialysis Treatment Kidney Transplant
Proper Diet or Medication
ESRD
There is no cure for chronic kidney disease, although treatment can slow or halt the progression of the disease. In the recent years, developing a simple and convenient adjuvant therapy with low risk of side effect has been concerned.
PROBIO-K complex powder can help CKD patients to maintain kidney function and reduce the risk of cardiovascular disease

4. Feature
Part I
The best three strains providing the best healing efficacy. 
Conduct stability assessment to ensure the quality of strains. 
All probiotic strains are correct strains by using TAF-certified DAN sequencing method, and are checked using API50 and PFGE strains as QC to avoid contamination and mutations.
Has been proved to survive in gastric acid and bile salts environment to reach and colonize in the intestine for proper function. 
It has been proved that probiotics have positive effects on inhibiting bad bacteria, preventing inflammatory bowel disease, reversing allergic reaction and regulating immune system, etc. Hence, using probiotics to replace antibiotics or help with treatment could reverse the side effects and improve the efficacy
Applied patented 5-layer micro-encapsulation protection.

5. Feature
Part II
Complete safety assessment to ensure product cause no harm to human body. 
Evaluated by a clinical study. Probiotic strains tested for antibiotic resistance. 
Clinically proved to maintain kidney function for chronic kidney disease patients.
Reduce the risk of cardiovascular disease. 
The study was conducted in cooperation with HungKaung University and Cheng Ching Hospital.
Improve the quality of life for chronic kidney disease patients. 

6. Exclusive Selected Strains
Lactobacillus salivarius LS159
Lactococcus lactis subsp. lactis LL358
Lactobacillus pentosus LPE588
The best combination of strains to help with treatment of chronic kidney disease

7. Lactococcus lactis subsp. lactis LL358
Clinically Proven
Lactococcus lactis subsp. lactis LL358

8. Maintain Kidney Function
PROBIO-BAC® PROBIO-K was proved to maintain kidney function for chronic kidney disease. Clinic trial indicated that taking PROBIO-K complex powder would lower blood urea nitrogen level and uric acid.
Uric acid (mg/dL)
Blood urea nitrogen (mg/dL)
Before taking PROBIO-K
Taking PROBIO-K for 12 weeks
Before taking PROBIO-K
Taking PROBIO-K for 12 weeks
Note: As kidney function gets worse, the kidney cannot remove blood urea nitrogen and uric acid from blood normally.
Fig. The effect of BUN and uric acid change of the third & forth stage CDK patients.

9. Lower Blood Glucose Levels
PROBIO-BAC® PROBIO-K was clinically proved to lower blood glucose levels with 65% of subjects. High blood glucose levels would increase kidney burden, but PROBIO-K was proved to enhance kidney protection.
Blood glucose (mg/dL)
Before taking PROBIO-K
Taking PROBIO-K for 12 weeks
Fig. The effect of blood glucose levels of the third & forth stage CDK patients.

10. Lower Triglyceride Levels
PROBIO-BAC® PROBIO-K was clinically proved to lower triglyceride levels with 63% of subjects, reducing the risk of cardiovascular disease.
Triglyceride(mg/dL)
Before taking PROBIO-K
Taking PROBIO-K for 12 weeks
Fig. The effect of triglyceride levels of the third & forth stage CDK patients.

11. The percentage of having improvement
Reduce Renal Toxicity
PROBIO-BAC® PROBIO-K was clinically proved to lower Indoxyl Sulfate(IS). Indoxyl Sulfate is regarded as a marker of renal dysfunction, also has a substantial role in the progression of CKD.
Toxicity
The percentage of having improvement IS
40.91%
Fig. The percentage of lowering IS levels of the third & forth stage CDK patients.

12. The percentage of having improvement
Improve the Quality of Life
PROBIO-BAC® PROBIO-K could help CDK patients to improve symptoms of fatigue, cramp, sleeping difficulty, constipation, dizziness and itchy skin.
Symptom
The percentage of having improvement
Fatigue
52.17%
Cramp
47.83%
Sleeping difficulty
39.13%
Constipation
34.78%
Dizziness
30.43%
Itchy skin
Fig. The improvement of symptoms of the third & forth stage CDK patients.

13. Patented Technology Patented 5-layer micro-encapsulation protection
(Patented No. M479761)
Lactic acid bacteria
Durable protection
Heat-resistant
Acid-resistant
Bile salt-resistant
Lysozyme-resistant,
Strong Colonization
Proved to survive in gastric acid and bile salts environment to reach and colonize in the intestine.

14. Certification
ISO22000
HACCP
GMP
Patented No. M479761
HALAL
ISO17025

15. Suitable For
 Keep a healthy kidney function
 Renal disease patient

16. Suggested Use
0.1~0.5 g/day (1.0~5.0╳1010CFU/day)

17. Supporting Document  SPEC  COA  MSDS  HALAL Certification
 DNA Verification
 Marketing Proposal