1. From: The Mechanism of the Initiation and Progression of Glioma
Date of download: 10/7/2017
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From: The Mechanism of the Initiation and Progression of Glioma
J. Appl. Mech. 2013;80(5): doi: /
Figure Legend:
These images from experiments by our group show that GBM cells (U87MG) differentiate in the presence of serum and express (a) the embryonic stem cell marker nestin (light contrast), (b) the neuronal differentiation marker β Tubulin III (light), and (c) the glial fibrillary acidic protein (GFAP) (light). When they are grown in the absence of serum in stem cell medium as neurospheres, they enrich for (d) nestin (light) but lose the expression of (e) β tubulin III and (f) GFAP. This shows how the fate of GSCs is driven towards stemness in a stem cell microenvironment, i.e., how the TME drives this fate.