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H. Mansell, L.J. Worobetz, T. Sylwestrowicz, A.S. Shoker 

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Presentation on theme: "H. Mansell, L.J. Worobetz, T. Sylwestrowicz, A.S. Shoker "— Presentation transcript:

1 A Retrospective Study of the Framingham Cardiovascular Risk Scores in a Liver Transplant Population 
H. Mansell, L.J. Worobetz, T. Sylwestrowicz, A.S. Shoker  Transplantation Proceedings  Volume 45, Issue 1, Pages (January 2013) DOI: /j.transproceed Copyright © Terms and Conditions

2 Fig 1 (A) Receiver operating characteristic (ROC) analysis to define patients at high Framingham risk score using Cockcroft-Gault equation. The area under the curve (AUC) was (0.726), significant at P < The 95% confidence interval was to Criterion fell at estimated glomerular filtration rate (eGFR) of 58.8 mL/min/1.73 m2. At this criterion level, the percentages of sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratio were 64.86, 75.00, 85.7, 48.00, 2.59, and 0.47, respectively. eGFR > 43.3 mL/min/1.73 m2 identified high-risk patients with sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratio at % of 91.89, 31.25, 75.6, 62.5, 1.34, and 0.26, respectively. (B) ROC analysis to define patients at high Framingham risk score using isotope dilution mass spectrometry equation. AUC was 0.703, significant at P < The 95% confidence interval was to Criterion fell at eGFR of 67.6 mL/min/1.73 m2. At this criterion level, the percentages of sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratio were 62.16, 81.25, 88.5, 48.1, 3.32, and 0.47, respectively. eGFR > 42.7 mL/min/1.73 m2 identified high-risk patients with sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratio at % of 91.89, 18.75, 72.3, 50.0, 1.13, and 0.43, respectively. Transplantation Proceedings  , DOI: ( /j.transproceed ) Copyright © Terms and Conditions

3 Fig 2 (A) Box plots represented estimated glomerular filtration rate measured by Cockcroft-Gault equation mL/min/1.73 m2 for liver transplantation patients at high, moderate, and low Framingham risks for cardiovascular disease. In all the box plots, the top of the box represents the 75th percentile, the bottom of the box represents the 25th percentile, and the line of the middle represents the 50th percentile. The whiskers (the lines that extend out the top and bottom of the box) represent the highest and the lowest values that are not outlier or extreme values. P value measured is from one-way analysis of variance (ANOVA). (B) Box plots represented estimated glomerular filtration rate measured by isotope dilution mass spectrometry mL/min/1.73 m2 for liver transplantation patients at high, moderate, and low Framingham risks for cardiovascular disease. In all the box plots, the top of the box represents the 75th percentile, the bottom of the box represents the 25th percentile, and the line of the middle represents the 50th percentile. Open circles represent outliers. P value measured is from one-way ANOVA. Transplantation Proceedings  , DOI: ( /j.transproceed ) Copyright © Terms and Conditions


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