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Characterisation of liver chemistry abnormalities associated with pazopanib monotherapy: A systematic review and meta-analysis of clinical trials in advanced.

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Presentation on theme: "Characterisation of liver chemistry abnormalities associated with pazopanib monotherapy: A systematic review and meta-analysis of clinical trials in advanced."— Presentation transcript:

1 Characterisation of liver chemistry abnormalities associated with pazopanib monotherapy: A systematic review and meta-analysis of clinical trials in advanced cancer patients  Thomas Powles, Sergio Bracarda, Mei Chen, Elliot Norry, Natalie Compton, Mark Heise, Thomas Hutson, Philipp Harter, Christopher Carpenter, Lini Pandite, Neil Kaplowitz  European Journal of Cancer  Volume 51, Issue 10, Pages (July 2015) DOI: /j.ejca Copyright © Terms and Conditions

2 Fig. 1 Cumulative incidence rate of ALT elevations over time for all ALT >3×ULN events (black line), all ALT >8×ULN events (medium grey line), and all ALT >3–8×ULN events (light grey line) in pazopanib-treated patients from the integrated database (N=2080). Abbreviations: ALT, alanine aminotransferase; ULN, upper limit of normal range. European Journal of Cancer  , DOI: ( /j.ejca ) Copyright © Terms and Conditions


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