1. Transformation is a multistep process

2. Colorectal Cancer 11% of cancer-related deaths
Tumor progression may take years
Adenomatous polyp develops into carcinoma

3. Chromosome changes in colorectal cancer
Cancer karyotype
Stable karyotype

4. reading
URLs:
Books:
Concepts of Genetics, Klug and Cummings, chapter 23
Molecular Biology of the Cell