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How do equivalent cells acquire different cell fates?

Published byFrancine Morgan Bennett Modified over 6 years ago

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Presentation on theme: "How do equivalent cells acquire different cell fates?"— Presentation transcript:

1 How do equivalent cells acquire different cell fates?

2 What is the major issue that the authors tried to address?
LIN-12 and Notch are similar proteins LIN-12 acts differently from Notch LIN-12 or Notch intracellular domain has an intrinsic biological activity How LIN-12 intracellular domain act to affect cell fate How Notch works in Drosophila

3 LIN-12(intra) acts like An activated LIN-12
A LIN-12 mutant without an activity A protein that gains a new function A protein that needs to act through another protein None of the above

4 Delta is A Notch-like receptor A putative Notch ligand
A protein that acts downstream of Notch A protein that antagonizes Notch activity None of the above

5 Notch is a membrane protein can be in the nucleus
acts downstream of Delta Normally suppresses the neural fate All of the above

6 What did you really learn from reading this paper?
How neurogenesis is regulated in flies How vulva development is regulated in worms. Notch and LIN-12 have a conserved acting mechanism LIN-12 and Notch look alike in structure None of the above

7 What is the most interesting question that is not resolved in this paper?
How does LIN-12 specify the AC and VU cell fate? How does Notch suppress the neural fate? How do Notch and LIN-12 acquire a conserved acting mechanism How do LIN-12 and Notch evolve to have similar structures Why is Notch observed on both plasma membrane and the nucleus?

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