1. Selin Palabıyıkoğlu 12-D
ANTACIDS
Selin Palabıyıkoğlu 12-D

2. Antacids are medicines that neutralize stomach acidity.
What is antacid?
Antacids are medicines that neutralize stomach acidity.

3. The stomach secretes:
Hydrochloric acid: the hydrogen ion concentration of the HCl normally cause pH to be between
Bicarbonate: helps buffer acidic properties of HCl
Pepsinogen: a precursor for the enzyme pepsin that breaks down proteins into peptides.
Mucus: protective barrier against HCl
These are known collectively as gastric juice.

4. Factors Affecting the Balance in the Stomach Mucosa
Aggressive Factors
Protective Factors
Stomach Acidity
Pepsin
Alcohol, nicotine
Anxiety
Helicobacter pylori sytotoxine (bacteria usually affecting the ulcer)
Drugs ( Aspirin and other analgesics)
Mucus production
Mucosal blood circulation
Cell repairing
Bicarbonate production
Acid related diseases can arise if the stomach lining is damaged or when too much acid is produced.

5. Acid Related Diseases Indigestion 2) Peptic Ulcer
3) Gastroesophageal Reflux Disease (GERD)

6. Indigestion
The discomfort caused by excess acid is known as indigestion and may result from overeating, alcohol, smoking, anxiety or in some people from eating certain types of food.

7. Peptic Ulcer
Peptic ulcers are localized wounds in the stomach, duodenum and lower esophagus mucosa with tissue destruction.
“Peptic” reflects a belief (probably misplaced) that peptic activity is related with pepsin.
The common symptom is pain occurring before meals or overnight, relieved by antacids, milk and food.

8. GERD
It is defined as present in an individual who experiences typical symptoms of GERD (heartburn, acid regurgitation to mouth, belching, globus sensation, chronic cough and hoarsenes), due to reflux of stomach contents into esophagus.
Mucosal injury may present or not.
It is a very common disorder affecting between 10-30% of western population.
Especially common in pregnant women and obese people.

9. Antacids
Antacids work by neutralizing the acid, preventing inflammation, relieving pain and discomfort, allowing the mucus layer and stomach lining to mend.
When used in the treatment of ulcers, they prevent acid from attacking the damaged stomach lining and so allow the ulcer to heal.
They are most affective if taken between one and three hours after eating, as food typically remains in the stomach for up to four hours after a meal.

10. Antacids are intended to treat digestive upset by raising the pH level of the stomach from a highly acidic 2 to between 3 and 4. This can neutralise up to 99% of the excess acid in the stomach, leading to substantial relief from symptoms for most people.
Raising gastric pH from 1.3 to 1.6 neutralizes 50% of the gastric acid.
Raising gastric pH 1 point (1.3 to 2.3) neutralizes 90% of the gastric acid.

11. Antacids are bases, usually, metal oxides, hydroxides, carbonates or hydrogen carbonates (bicarbonates) to neutralize excess acidity.
They begin to work within a minute and can provide a relief that ranges from 10 minutes to more than 90 minutes.

12. Action of Antacids
Magnesium Oxide: MgO(s)+ 2HCl(aq)  MgCl2(aq) + H2O(l)
Magnesium Hydroxide: Mg(OH)2(aq)+2HCl(aq) MgCl2(aq)+ 2H2O(l)
Aluminum Hydroxide: Al(OH)3(s)+3HCl(aq) AlCl3(aq)+ 3H2O(l)
Calcium Carbonate: CaCO3(s) + 3HCl (aq)  CaCl2(aq)+H2O(l)+CO2(g)
Sodium Bicarbonate: NaHCO3(aq)+HCl(aq)NaCl2(aq)+H2O(l)+CO2(g)
Magnesium Trisilicate:
Mg2Si3O8(s)+4HCl(aq)3SiO2(s)+2H2O(l) +2MgCl2(aq)

13. Antacids are combined with chemicals called alginates that produce a neutralising layer that prevents acid reflux. They prevent acid in the stomach from rising into the esophagus and causing “heartburn”.
Similarly, anti-foaming agents, such as dimethicone or simethicone are added to reduce the surface tension of gas bubbles, causing them to come together, producing a defoaming action.

14. BRAND NAME
INGREDIENTS
Tums®
CaCO3, MgCO3, MgSi3O8 (magnesium trisilicate)
Rennie®
CaCO3, MgCO3, NaC6H7O (sodium alginate)
Rotaids®
AlNa(OH)2CO3 (dihidroxylaluminum sodium carbonate
Dank®, Kompensan®
AlNa(OH)2CO3
Maalox®
Asidal®, Mucaine®, Simeco®
Mg(OH)2, Al(OH)3 , simethicone
Di-Gel®
CaCO3
Alca-Seltzer®
NaHCO3, citric acid, aspirin
Milk of Magnesia®
Mg(OH)2
Amphogel®
Al(OH)3

16. Side Effects
Side effects are very rare. They are more likely when the medicine is taken large doses or over a long time.

17. Aluminum Compounds
constipation or irregularity
prevent uptake of phosphate ions causing possible bone damage if taken in high doses over a long period
Magnesium Compounds
diarrhea
Calcium Carbonate
excessive amount of calcium ions being absorbed into the body
kidney stones
Sodium Ions
hypertension
Excessive use of Sodium Bicarbonate
alkalosis ( alkaline stomach causes discomfort and is often mistaken as being due to an acidic stomach so one takes more antacid, making the stomach still more alkaline, causing more indigestion)
fluid retention ( bloating)

19. Precautions
Antacids should not be given to children under 6 years old.
Before combining antacids with extra calcium ( dairy products or calcium supplements) ask for assistance.
Be careful in low-sodium diet( hypertension cases)
Occasional use of antacids in small amounts is safe during pregnancy.
Magnesium containing antacids should be avoided in patients with chronic kidney failure.
Absorbtion of some antibiotics and iron inhibited by antacids.

20. Acid “Rebound”
Antacids show the most rapid action but may cause acid “rebound”: a condition in which the gastric acid return in greater concentrations after the drug effect has stopped.

21. Remember that;
Antacids DO NOT prevent the overproduction of acid.
Antacids DO neutralize the acid once it’s in the stomach.

22. Questions
1) Which would be the most effective in combating indigestion- a spoonful of liquid containing 1.00 g of magnesium hydroxide, or a spoonful of liquid containing 1.00 g of aluminum hydroxide?

23. 2) One common type of drug taken orally is antacid
2) One common type of drug taken orally is antacid. Antacids such as sodium hydrogencarbonate are taken to reduce stomach acidity.
State the names of two metals, other than sodium, whose compounds are often used in antacids.
Give an equation for the neutralization of HCl in the stomach by sodium hydrogencarbonate.
Explain how heartburn is caused.
Explain why dimethicone is added to some antacids.