1. Awards and Honors National Medal of Science
Rakesh Jain, PhD (Radiation Oncology)
National Academy of Engineering
Emery N. Brown, MD, PhD (Anesthesia)
National Academy of Sciences Jeannie Lee, M.D., Ph.D. (Molecular Biology and Pathology)
National Academy of Medicine (NAM, formerly the IOM)
Joan W. Miller, MD (Ophthalmology)
German National Academy of Sciences, the Leopoldina
Ralph Weissleder, MD, PhD (Center for Systems Biology)

2. Awards and Honors (cont’d)
National Institutes of Health (NIH) New Innovator Award
Alek K. Shalek, PhD (Ragon Institute)
NIH Early Independence Award
Shadmehr (Shawn) Demehri, MD, PhD (Dermatology & Cancer Center)
National Cancer Institute (NCI) Outstanding Investigator Award
Rakesh Jain, PhD (Radiation Oncology)
National Institute of Neurological Disorders and Stroke (NINDS) Javits Neuroscience Award
Kevin Staley, MD (Pediatric Neurology)
Endocrine Society’s Laureate Outstanding Mentor Award Anne Klibanski, MD (Neuroendocrine)

3. Awards and Honors (cont’d)
Smithsonian American Ingenuity Award
Rudolph E. Tanzi, PhD & Doo Yeon Kim, PhD (Neurology)
Blavatnik National Awards for Young Scientists (Finalist)
Hakho Lee, PhD (Center for Systems Biology)
Bill & Melinda Gates Foundation Grand Challenges Explorations
Alessio Fasano, MD, Christina Faherty, PhD, and Stefania Senger, PhD (Pediatrics)
2015 Joseph B. Martin Dean’s Leadership Award for the Advancement of Women Faculty
Merit Cudkowicz, MD (Neurology)
John Eisenberg National Award for Career Achievement in Research Nancy Rigotti, MD (Internal Medicine)

4. Awards and Honors (cont’d)
Jacobson Innovation Award Joseph Vacanti, MD (Pediatric Surgery)
Paul Marks Prize for Cancer Research
Bradley Bernstein, MD, PhD (Pathology)
Time Magazine’s “100 Most Influential People”
Rudolph E. Tanzi, PhD (Neurology)

5. FY1992 – FY2015 NIH Extramural Awards to Top Local Independent Hospitals
Total Awards ($ millions)
MGH
BWH
UPDATED

6. MGH Total Research Revenue Trend (Including Other Science)
MGH combined research has grown at a compounded annual growth rate of 7.4% between FY2000 and FY15. The 5-year moving average annual growth has decreased from 7.1% in FY10 to 4.2% in FY15; the FY14-FY15 growth was 5.3%, with increases across every sponsor category.
Direct & Indirect Research Expenditures ($ 000’s)
UPDATED
Other science encompasses research support functions such as animal facilities, cores, and exchange accounts
50%
43%

7. MGH Research by Sponsor FY15 Direct and Indirect Revenues $800,206,486
1% from 2014,
7% from 2012
UPDATED
We are up from $760M in FY14 - primarily driven by an increase in endowment and gifts,
Note: Other Gov't includes Other Federal and State/Local
Note: Other Gov't includes Other Federal and State/Local

8. MGH Research by Department FY15 Direct and Indirect Revenues $800M
(Shown in $Millions)
UPDATED
Notes:
1- Expenditures include ARRA funding and Other Science
2- Surgery includes Pediatric Surgery, Oral Surgery and Urology
3- Other includes Administrative Departments

9. Proposals FY15 vs. FY14
4,373 proposals submitted in FY15, up 10% versus FY14
Fiscal Year
DHHS
Foundations
Industry/ Corporate
Non-Profit
Other Federal
All Other Sponsors
Total
2014
1,018
651
448
1,277
173
407
3,974
2015
1,160
635
563
1,500
150
365
4,373
Difference
142
(16)
115
223
(23)
(42)
399
% Change
14%
-2%
26%
17%
-13%
-10%
10%
Note: All Other Sponsors include Internal, Miscellaneous, and state/local sponsors. Excludes confidentiality agreements.

10. New Award Trends
MGH has the highest number and amount of new awards of any institution within Partners.
Although FY14 was an exceptionally good year, our new award amounts for FY15 still surpass that of FY12 & FY13
Note:
-New award volumes are based on the number of parent proposal awards.
-New award amounts include total budget amounts for all years of project.
PHS, Research Analytics. Source: Micro Strategy

11. NIH Funding Market Share Trends
MGH accounts for 1.6% of the NIH Budget
BWH accounts for 1.5% of the NIH Budget
Partners overall accounts for 3.2% of the NIH Budget
Our share is increasing: FY07 1.3%; FY13 1.5%; FY15 1.6%
Source: NIH Funding Report, US. Department of Health and Human Services

12. FY15 NIH Extramural Awards Ranking: All Institutions
ORGANIZATION
AWARDS
FUNDING 1
JOHNS HOPKINS UNIVERSITY
1235
$584,714,172 2
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
1223
$560,409,410 6 3
UNIVERSITY OF MICHIGAN
1059
$453,368,007 4
UNIVERSITY OF PENNSYLVANIA
1094
$453,359,803 5
UNIVERSITY OF WASHINGTON
896
$434,224,865
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
953
$430,310,349 8 7
STANFORD UNIVERSITY
929
$422,361,283 9
UNIVERSITY OF CALIFORNIA SAN DIEGO
841
$388,697,641
UNIV OF NORTH CAROLINA CHAPEL HILL
874
$379,585,711 10
WASHINGTON UNIVERSITY
823
$378,098,015 12 11
UNIVERSITY OF CALIFORNIA LOS ANGELES
860
$370,715,745 14
DUKE UNIVERSITY
740
$362,975,831 13
YALE UNIVERSITY
864
$352,512,800
MASSACHUSETTS GENERAL HOSPITAL
771
$351,565,758 15
BRIGHAM AND WOMEN'S HOSPITAL
539
$333,214,883 16
COLUMBIA UNIVERSITY HEALTH SCIENCES
805
$331,381,051 18 17
EMORY UNIVERSITY
679
$311,143,869
VANDERBILT UNIVERSITY
755
$303,248,528 19
UNIVERSITY OF WISCONSIN-MADISON
617
$270,626,069 22 20
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
510
$265,532,222

13. FY15 NIH Ranking: Independent Hospitals
ORGANIZATION
AWARDS
FUNDING 1
MASSACHUSETTS GENERAL HOSPITAL
771
$351,565,758 2
BRIGHAM AND WOMEN'S HOSPITAL
539
$333,214,883 3
CHILDREN'S HOSPITAL BOSTON
319
$137,431,827 4
DANA-FARBER CANCER INST
220
$125,295,828 5
CHILDREN'S HOSP OF PHILADELPHIA
202
$114,023,148 6
BETH ISRAEL DEACONESS MEDICAL CENTER
236
$112,741,707 7
CINCINNATI CHILDRENS HOSP MED CTR
257
$98,324,805 8
ST. JUDE CHILDREN'S RESEARCH HOSPITAL 94
$66,612,466 9
NEW YORK STATE PSYCHIATRIC INSTITUTE 93
$44,789,229 12 10
CEDARS-SINAI MEDICAL CENTER 95
$41,464,366 11
SEATTLE CHILDREN'S HOSPITAL 84
$38,150,472 16
NATIONAL JEWISH HEALTH 56
$35,256,665 13
BOSTON MEDICAL CENTER 78
$30,632,865 15 14
ROSWELL PARK CANCER INSTITUTE CORP 67
$28,371,593
MCLEAN HOSPITAL 83
$26,164,845 17
RHODE ISLAND HOSPITAL
$24,289,073
TUFTS MEDICAL CENTER 43
$22,453,135 18
CHILDREN'S HOSPITAL OF LOS ANGELES 48
$22,263,973 19
MASSACHUSETTS EYE AND EAR INFIRMARY 42
$20,663,625 46
SPAULDING REHABILITATION HOSPITAL
$1,337,483

14. Support for Researchers

15. Faculty Support Special Grants Program for Faculty
Goodman Award: 300K
Martin Prizes (basic/clinical): 100K
Claflin Awards: $100K
Multicultural Awards:
Postdoctoral Fellowships
Tosteson and Fund for Medical Discovery (FMD) Awards
22 40K each
Clinical Research FMD – 4 $40K
ECOR Institutional Support
For Shared Instrumentation Grant (SIG) applications
FY15 budget – $500,000
New for FY15: two Multicultural Grants

16. Faculty Support (continued)
Interim Support Fund (ISF)
Provides funding to bridge programs with grant scores that are good but are not fundable
The number of worthy applications has increased as the pay line at NIH has decreased
NIH now commonly does not fund the first competing submission (the ‘A’) but funds the second (‘A1’) creating a situation where funding gaps are becoming the norm
In FY15, we awarded $7.6M to 87 investigators
--- “Updates to Program” slide deleted from Oct 2015 slide deck ---
Increased interim support
from $50,000 to $75,000
Additional ISF funds available **under exceptionally difficult circumstances**
A maximum of $150,000 in total extra funds
This extra support will be sourced 50:50 with Dept
$150,000 ($75K base + $75K additional) from ECOR
$ 75, sourced from Department
$225, maximum total award

17. Return on Investment ROI = Gain from Investment – Cost of Investment
ECOR Grants
NIH Grants
Grants
Total ECOR Awarded
Total NIH Awarded
ROI
Formulaic
270
$16,905,500
156
$259,790,332
14:1
Deliberative
368
$25,475,263
118
$179,494,823
6:1
Total
638
$42,380,763
274
$439,285,155
9:1
ISF Awards and NIH Funds Received from 2006 – March 2016
revised version with added materials per Slavin request

18. ECOR Administered Support Programs
The MGH Research Scholars
The MGH Research Institute Chair
The MGH Committee on Awards & Honors
MGH-MIT Strategic Partnership
Limited Submissions & Institutional Nominations

19. MGH Research Scholars Launched in 2011
Goal: Support outstanding MGH investigators doing fundamental, translational and clinical research
Award: $100K per year for five years
May Research Scholars (of 115 applicants)
May Research Scholars (of 98 applicants)
March Research Scholars (of 81 applicants)
March Research Scholars (of 95 applicants)
March Research Scholars (of 77 applicants)
March Research Scholars (of 91 applicants)

20. Why do we need the Research Scholars Program ?
Responsive to SAC’s feedback to provide hard money support for researchers
Maximize efficiency of our top researchers, especially the rising stars.

21. The First MGH Research Institute Chair
Announcing the Bernard and Mildred Kayden Endowed MGH Research Institute Chair
We are thrilled to announce a significant milestone for the Massachusetts General Hospital Research Institute. Thanks to a generous and visionary gift from The Kayden Foundation, we have established the first endowed chair within the Research Institute to foster and accelerate cutting-edge innovation at Mass General in perpetuity.   Mass General frequently establishes chairs to honor physicians in specific specialties. However, the Research Institute’s endowed chairs are intended to honor outstanding investigators whose work may intersect multiple disciplines and departments, and whose work we believe will play an important role in preventing disease and improving patient care for generations to come.   This newly endowed position will be named the Bernard and Mildred Kayden Endowed MGH Research Institute Chair. The Kayden Foundation was motivated to make this gift by what it sees as “the silo-busting aspects of the Research Institute” and the difference that hard funding can make in the work of outstanding scientists.   The Research Institute Steering Committee solicited nominations from all of the Mass General’s chiefs and center directors. An impressive list of more than 40 worthy scientists was generated, and the Research Institute Steering Committee chose Bradley E. Bernstein, MD, PhD, as the inaugural incumbent of the Bernard and Mildred Kayden Endowed MGH Research Institute Chair.   Dr. Bernstein is a pathologist at Mass General, an Institute Member of the Broad Institute of Harvard and MIT, and a professor in the department of pathology at Harvard Medical School. Dr. Bernstein leads a vibrant research group within an interactive academic community. He has successfully directed diverse and pioneering projects in genomics, technology development, chromatin, stem cell and cancer biology. Dr. Bernstein’s research group innovates and applies genomic tools to study chromatin and epigenetic gene regulation in stem cells and tumor models. These studies have advanced the understanding of gene regulatory elements, chromatin states and epigenetic mechanisms in development and disease.   Dr. Bernstein’s work has received numerous awards and recognitions that have included the Mass General Howard M. Goodman Fellowship in 2006, a Howard Hughes Medical Institute Early Career Scientist award in 2009, the Mass General Martin Prize for Basic Science in 2012, and the Paul Marks Prize for Cancer Research from Memorial Sloan Kettering Cancer Center in He also received a coveted American Cancer Society Research Professorship in Dr. Bernstein has authored over 100 peer-reviewed publications.   We are excited to name Dr. Bernstein as the first incumbent of the Bernard and Mildred Kayden Endowed MGH Research Institute Chair and we are confident that his commitment to scientific inquiry will help to advance research in the field of epigenetics for years to come. Please join us in congratulating Dr. Bernstein.  
Bradley E. Bernstein, MD, PhD

22. MGH Committee on Awards and Honors
Ensures an MGH nominee for >40 major national and international scientific awards, prizes, and endorses faculty members for admission to distinguished honorific societies
Established in summer 2014
Committee of 15 esteemed institution leaders chaired by Dr. Sam Thier
Championed the nominations of more than 23 outstanding scientists for major awards and society memberships in 2015
1st success story – Jeannie Lee, PhD (Mol Bio/Path) nominated for and won the 2016 Lurie Prize
The Lurie Prize recognizes outstanding achievement by a promising young scientist in biomedical research.  The Prize is $100,000 and was first awarded in 2013.  At the suggestion of the MGH Awards and Honors Committee chaired by Dr. Samuel Thier, Bob Kingston, PhD, (Molecular Biology) nominated Jeannie Lee, PhD (Molecular Biology) for the 2016 Lurie Prize.  As a result Jeannie Lee was selected and she will be awarded the Lurie Prize “for uncovering the functions of long, noncoding RNA (lncRNA) in epigenetic regulation. Her work has accelerated the understanding of mechanisms driving epigenetic regulation, which involves changes in gene function without changing the DNA sequence.”  The Prize will be presented to Jeannie Lee at the Foundation for the National Institutes of Health (FNIH) Award Ceremony in May 2016.

23. Committee Members Anne Klibanski, MD Samuel Thier, MD - Chair
John Potts, MD
Paul Russell, MD
Gary Ruvkun, PhD
Jack Szostak, PhD
James Thrall, MD
Anne Young, MD
Samuel Thier, MD - Chair
Dennis Ausiello, MD
Frederick Ausubel, PhD
Patricia Donahoe, MD
Lisa Iezzoni, MD, MSc
Kurt Isselbacher, MD
Rakesh Jain, PhD
Staff:
Harry Orf, PhD
Maire Leyne, MS, MBA
Karen Osborne Greene