1. SciLifeLab DDD Platform – built for function
Operational since Q2-2014
40+ Industrially experienced scientists
12 Academic professors – Area expertize and network
National Platform board – Project prioritization, budget and strategy
Håkan Billig (GU, Chair), Tommy Olsson (UmU), Maria Jenmalm (LiU), Mef Nilbert (LU) Anna Sandström (AZ), Kjell Sackariassen (KellSA), Bo Öberg (ex Medivir)
Per Arvidsson
Kristian Sandberg
Target product profiling & Drug safety assessment
Distribute compounds in assay ready plates from the SciLifeLab compound collection
Compound Center
Platform and project coordination. Assessment of liabilities driven by target, SM or Biologics. Support to PI’s and Innovation offices
Protein expression & characterization
Human antibody therapeutics
Selection and characterization of therapeutic antibody candidates from IP - free human phage libraries SciLifeLib 1 & 2
Prepare, purify and characterize proteins from E. coli, insect and transient HEK cells
Protein
Prepare, compare and design lead molecules with a promising profile for proof-of-concept in vivo. Access to radio chemistry and peptide chemistry
Medicinal chemistry –
Lead ID
Medicinal chemistry -
Hit2Lead
Prepare, compare and design lead molecules with a promising profile for proof-of-concept in vivo.
Chemistry
Biochemical and cellular screening
Investigate drug MoA for product differentiation and identification of putative biomarkers
In vitro & systems pharmacology
Develop and run assays required to drive chemistry and to confirm functional binding of antibodies
Assays
Biophysical screening & characterization
ADME (UDOPP)
Identify and characterize ligands, structural biology & fragment based lead generation
Determine absorption, distribution, metabolism, excretion (ADME) and perform pharmaceutical profiling