1. FIGURE 1. Infusion cannula
FIGURE 1. Infusion cannula. The infusion cannula consists of a 1-ml, gas-tight, Luer-lock glass syringe, filled with sterilized sesame seed oil, linked to oil and loading chambers made from different lengths of Teflon tubing.
From: Multicolumn Infusion of Gene Therapy Cells into Human Brain Tumors: Technical Report
Neurosurgery. 2000;46(3): doi: /
Neurosurgery |

2. FIGURE 2. Stereotactic targeting of columns
FIGURE 2. Stereotactic targeting of columns. An axial, contrast-enhanced, magnetic resonance imaging scan of a recurrent right parieto-occipital glioblastoma is presented. The three infusion columns are indicated by thickening of the cannula trajectories, and the sites of initiation of infusion are indicated by circles.
From: Multicolumn Infusion of Gene Therapy Cells into Human Brain Tumors: Technical Report
Neurosurgery. 2000;46(3): doi: /
Neurosurgery |

3. FIGURE 3. Infusion system
FIGURE 3. Infusion system. A, slave cylinder of the micropositioner, with an infusion cannula attached. B, intraoperative photograph of the infusion cannula mounted on the arc of the CRW stereotactic frame.
From: Multicolumn Infusion of Gene Therapy Cells into Human Brain Tumors: Technical Report
Neurosurgery. 2000;46(3): doi: /
Neurosurgery |

4. FIGURE 4. Volumetric targeting
FIGURE 4. Volumetric targeting. A, three-dimensional diagrammatic representation of five infusion cannulae placed at different depths within an ovoid tumor. B, three-dimensional representation of circular slices through the ovoid tumor (r = radius), which were used to calculate its volume as MATH π(−5/9 x² )² = 7.85 cc. C, cross section through the equator of the tumor, depicting both the intersection of the cannulae with the tumor plane and the surrounding 0.4-cm-diameter range of tumoricidal activity.
From: Multicolumn Infusion of Gene Therapy Cells into Human Brain Tumors: Technical Report
Neurosurgery. 2000;46(3): doi: /
Neurosurgery |

5. FIGURE 5. Tumor saturation
FIGURE 5. Tumor saturation. This graph illustrates the increase in the total volume of VPC columns and the percentage of the tumor volume that is saturated with tumoricidal effect as the number of cannulae increases.
From: Multicolumn Infusion of Gene Therapy Cells into Human Brain Tumors: Technical Report
Neurosurgery. 2000;46(3): doi: /
Neurosurgery |