1. Human Physiology Respiratory System
by Talib F. Abbas

2. Pulmonary circulation
The blood volume of the lungs is about 450 milliliters.
The blood flow through the lungs is essentially equal to the cardiac output.
Under most conditions, the pulmonary vessels act as passive, distensible tubes that enlarge with increasing pressure and narrow with decreasing pressure.
the concentration of oxygen< 73 mm Hg Po2= blood vessels constrict.
This causes the blood to flow through other areas of the lungs that are better aerated,
thus providing an automatic control system .

3. Effect of Hydrostatic Pressure in the Lungs
blood pressure in the foot of a standing person can be as much as 90 mm Hg greater than the pressure at the level of the heart= hydrostatic pressure.
the pulmonary arterial pressure in the uppermost portion of the lung of a standing person is about 15 mmHg less than the pulmonary arterial pressure at the level of the heart, and the pressure in the lowest portion of the lungs is about 8 mm Hg greater. Such pressure differences have profound effects on blood flow through the different areas of the lungs.

4. Function of the Pulmonary Circulation
As a result, the left atrial pressure can rise on occasion from its normal value of 1 to 5 mm Hg all the way up to 40 to 50 mm Hg. The initial rise in atrial pressure, up to about 7 mm Hg, has very little effect on pulmonary circulatory function. But when the left atrial pressure rises to greater than 7 or 8 mm Hg, further increases in left atrial pressure above these levels cause almost equally great increases in pulmonary arterial pressure, thus causing a concomitant increased load on the right heart.

6. Pulmonary Edema the pulmonary interstitial fluid pressure to rise .
The most common causes of pulmonary edema are as follows:
1. Left-sided heart failure or mitral valve disease, with consequent great increases in pulmonary venous pressure and pulmonary capillary pressure and flooding of the interstitial spaces and alveoli.
2. Damage to the pulmonary blood capillary membranes caused by infections such as
pneumonia or by breathing noxious substances such as chlorine gas or sulfur dioxide gas. Each of these causes rapid leakage of both plasma proteins and fluid out of the capillaries and into both the lung interstitial spaces and the alveoli.

7. Gas transport between the lung and Tissue
The O2 delivery system in the body consists of the lungs and the cardiovascular system.
The amount of O2 in the blood is determined by the amount of dissolved O2, the amount of hemoglobin in the blood, and the affinity of the hemoglobin for O2.
partial pressure .
Effect of Rate of Blood Flow on Interstitial Fluid PO2.
Effect of Rate of Tissue Metabolism on Interstitial Fluid PO2.

8. Gas transport

9. Carbon dioxide diffusion
carbon dioxide can diffuse about 20 times as rapidly as oxygen because
1. Intracellular Pco2, 46 mm Hg; interstitial Pco2, 45 mm Hg. Thus, there is only a 1 mm Hg pressure differential.
2. Pco2 of the arterial blood entering the tissues, 40 mm Hg; Pco2 of the venous blood leaving the tissues, 45 mm Hg. Thus, the tissue capillary blood comes almost exactly to equilibrium with the interstitial Pco2 of 45 mm Hg.
3. Pco2 of the blood entering the pulmonary capillaries at the arterial end, 45 mm Hg; Pco2 of the alveolar air, 40 mm Hg. Thus, only a 5 mm Hg pressure difference causes all the required carbon dioxide diffusion out of the pulmonary capillaries into the alveoli

10. PCO2 diffusion

11. Role of Hemoglobin in Oxygen Transport
oxygen is carried to the tissues almost entirely by hemoglobin.
Reversible Combination of Oxygen with Hemoglobin
It was pointed out that the oxygen molecule combines loosely and reversibly with the heme portion of hemoglobin. When Po2 is high, as in the pulmonary capillaries, oxygen binds with the hemoglobin, but when Po2 is low, as in the tissue capillaries, oxygen is released from the hemoglobin. This is the basis for almost all oxygen transport from the lungs to the tissues.

13. Oxygen-Hemoglobin Dissociation Curve:
The oxygen-hemoglobin dissociation curve, which demonstrates a progressive increase in the percentage of hemoglobin bound with oxygen as blood Po2 increases, which is called the per cent saturation of hemoglobin. Because the blood leaving the lungs and entering the systemic arteries usually has a Po2 of about 95 mm Hg, one can see from the dissociation curve that the usual oxygen saturation of systemic arterial blood averages 97 per cent. Conversely, in normal venous blood returning from the peripheral tissues, the Po2 is about 40 mm Hg, and the saturation of hemoglobin averages 75 per cent.

14. Factors That Shift the Oxygen-Hemoglobin Dissociation Curve
oxygen-hemoglobin dissociation curves are for normal, average blood. However, a number of factors can displace the dissociation curve in one direction or the other. when the blood becomes slightly acidic, with the pH decreasing from the normal value of 7.4 to 7.2, the oxygen-hemoglobin dissociation curve shifts, on average, about 15 per cent to the right. Conversely, an increase in pH from the normal 7.4 to 7.6 shifts the curve a similar amount to the left. In addition to pH changes, several other factors are known to shift the curve. Three of these, all of which shift the curve to the right, are (1) increased carbon dioxide concentration, (2) increased blood temperature, and (3) increased 2,3- biphosphoglycerate (BPG), a metabolically important phosphate compound present in the blood in different concentrations under different metabolic conditions.

16. oxygenhemoglobin dissociation curve to the right
Average, about 15 per cent to the right. Conversely, an increase in pH from the normal 7.4 to 7.6 shifts the curve a similar amount to the left. In addition to pH changes, several other factors are known to shift the curve. Three of these, all of which shift the curve to the right, are (1) increased carbon dioxide concentration, (2) increased blood temperature, and (3) increased 2,3-biphosphoglycerate (BPG), a metabolically important phosphate compound present in the blood in different concentrations under different metabolic conditions.
Increased Delivery of Oxygen to the Tissues When Carbon Dioxide and Hydrogen Ions Shift the Oxygen-Hemoglobin Dissociation Curve—The Bohr Effect.

17. Bohr Effect
which can be explained as follows: As the blood passes through the tissues, carbon dioxide diffuses
from the tissue cells into the blood. This increases the blood Po2, which in turn raises the blood H2CO3 (carbonic acid) and the hydrogen ion concentration. These effects shift the oxygen-hemoglobin dissociation curve to the right and downward, forcing oxygen away from the hemoglobin and therefore delivering increased amounts of oxygen to the tissues. Exactly the opposite effects occur in the lungs, where carbon dioxide diffuses from the blood into the alveoli. This reduces the blood Pco2 and decreases the hydrogen ion concentration, shifting the oxygen- hemoglobin dissociation curve to the left and upward

18. Shift of the dissociation curve during exercise
The exercising muscles, in turn, release large quantities of carbon dioxide; this and several other acids released by the muscles increase the hydrogen ion concentration in the muscle capillary blood. In addition, the temperature of the muscle often rises 2° to 3°C, which can increase oxygen delivery to the muscle fibers even more. All these factors act together to shift the oxygen hemoglobin dissociation curve of the muscle capillary blood considerably to the right

19. HYPOXIA Hypoxia is O2 deficiency at the tissue level
(1) hypoxic hypoxia, in which the PO2 of the arterial blood is reduced;
(2) anemic hypoxia, in which the arterial PO2 is normal but the amount of hemoglobin available to carry O2 is reduced;
(3) stagnant or ischemic hypoxia, in which the blood flow to a tissue is so low that adequate O2 is not delivered to it despite a normal PO2 and hemoglobin concentration;
(4) histotoxic hypoxia, in which the amount of O2 delivered to a tissue is adequate but, because of the action of a toxic agent, the tissue cells cannot make use of the O2 supplied to them.

20. Thank you