1. “Ethical, Legal and Psychological Aspects of Organ Transplantation”

2. Why is Organ Donation important?
-There are more than 87,000 patients listed awaiting an organ transplant.
-Organ transplants come from Cadaveric donors and by Living donors.
However, the issue that exists is a Supply & Demand Problem.

3. Newsroom Facts
On average, 115 people are added to the nation’s organ transplant waiting list each day – ONE EVERY 13 MINUTES
On average, 66 people receive transplants every day from either a living or deceased donor.
More than 2,200 children under the age of 18 are on the transplant waiting list.

4. Medical Staff Ethical Dilemmas
Admitting failure: A patient has died
Stepping aside
Supporting or Obstructing Patient Management

5. Ethical Issues of Transplant Recipients
Retransplantation: How many times can a person be transplanted when others are also waiting?
Prisoners: Before and now with today’s DNA evidence?
Non-resident aliens?
Multiple Listing: Being registered at more than one transplant center?

6. Does being a celebrity or being rich influence listing?
UNOS allows for multiple listing for certain organs, i.e. Liver,
However having available money to travel at a moment’s notice would help an individual but not change their place on the waiting list.

8. The first Heart Transplant
Christiaan Barnard, a south African surgeon, was 44 years old when in 1967 he transplanted the heart of a 25 year old woman into the body of a dying 55 year old man.

9. The patient lived 18 days, dying from rejection of the organ
The patient lived 18 days, dying from rejection of the organ. Reactions were mixed, the prevailing medical opinion being that the operation had been premature.

10. Types of transplants Living donor (lobe of the liver or a kidney)
Directed or non-directed. Sweden in 2004.
instituted non-directed, compensated donations
Cadaver (brain-dead)
90% of organs come from these individuals ( /year). (Bresnahan 2010)

11. Quality of life for donors and recipients
Cyclosporin, which blocks immune rejection of foreign tissue, was discovered in the early 1980s.
Today 75% of heart transplant patients survive for at least five years and 50-60% survive 10 years.
Over 60% of lung transplant patients survive over five years.

12. Risk for donors
In Iran there is a regulated market for kidneys. A study in 2001 shows that vendors frequently feel worthless and shameful. Akin to prostitutes. Anxiety and depression. (Kerstein 2009)
However some argue that organ selling may improve the vendor’s situation. (Cherry 2000)
In US (Omar 2010) only 0.03% mortality

13. Criteria of death
For thousands of years death included cessation of breathing and heartbeat. This is the whole-body standard of death.
This definition became inappropriate when ventilators were developed that allowed artificial respiration of brain-damaged patients.

14. Criteria of brain death
Harvard criteria (1968): Very cautious: no behavior that indicated consciousness , flat EEG readings 24 hours apart. No brain activity.
Cognitive criterion: not legal in any state. Loss of “core properties” of a person.
Irreversibility standard. Unconsciousness is irreversible. Persistent vegetative state over one year

15. Uniform Brain Death Act. Loss of all brain function.
In several religions the ethics of brain dead organ donation continues to be controversial.
Conflicting Needs:
Doing everything possible for a comatose or dying patient
Allowing families closure and obtaining organs for transplantation

16. A few patients can make good recovery after being comatose for over a year. (7/434)

17. Shortage of organs
There is a growing disparity between demand for and supply of organs. (Hippen 2009)
In 2009 worldwide 102,000 on transplant list. In 2008 fewer than 8000 donors and fewer than 22,000 transplanted organs. 15% of patients die on the liver transplant waiting list annually.

18. Ethic of Care
Captures the moral situation of live kidney donations (Kane 2008)
Focuses on the concrete and contextual, concentrates on relationships.
“animism” : donor’s qualities are imagined to live within the recipient.

19. Advantages of kidney transplant
Transplantation confers a good quality and longer life cf. to dialysis. Also cheaper. Currently 6% of Medicare spent on .6% of recipients.
Dialysis: blood run through a filtering membrane and returned to body. 3 x week for 4-5 hours each session.

20. Need for organs for transplant
Which system would more successfully realize the goals of greater availability?
free market, state-regulated market, or blanket prohibition

21. Possible exploitation
To exploit someone is to benefit by taking unfair advantage of that person.
International data: individuals who have sold their kidneys for cash are not financially improved 5 years later and describe their health and overall well-being as worse.

22. Black market in organs
41% of surveyed physicians believed they had treated a patient who had purchased an organ.

23. Should there be a market for organs?
Monetary compensation is prohibited in US by National Organ Transplantation Act but some in the professional transplant community argue for a regulated commercial market for living kidney donations. (Aronsohn et al 2010)

24. Transplant professionals in US
A majority opposed to a market for kidneys and partial livers.
Liver transplants more risky.
Risk: quality of life vs. surgical risk
Market value of living kidney graft: $ ,549
Market value of living partial liver graft: $18,663-69,080

25. Main criticisms of regulated market
It would exploit vulnerable vendors and recipients: gray-market transactions in developing countries.
Two Kant-based moral constraints which some argue would make regulated organ market immoral:
1. violates human dignity and incomparable worth

26. Organ market 2. treats others merely as a means.
In the world as we know it the organ market would be immoral.
For Kant everything that lacks incomparable worth has mere price, including human happiness and well-being
Living donors are otherwise healthy people who voluntarily submit to surgery. Currently their donation is a gift not a sale.

27. Alternatives to a market in organs
Opt-out programs: citizens are presumed to consent to donating their organs at death but can opt out of donation if they choose. (Spain has this system and has the highest deceased donor rate in the world). (Kerstein 2009)

28. Autonomy
Even those transplant physicians who support an organ market rated risk more important than patient autonomy and opportunity to earn money.
Also there is human flourishing, which would be diminished by a market.

29. Possible non-monetary incentives
Guaranteed health insurance, life insurance, payment for lost wages, etc.

30. Utilitarian considerations
In the U.S. prison inmates are entitled to organ transplants
An inmate on Oregon’s death row requested a kidney transplant, which would have saved Oregon money. But there are more than 59,000 Americans waiting for kidneys, nearly 200 in Oregon.

31. Reasons for transplant for inmate
Morally wrong to reduce an inmate’s quality of life whether he is eventually executed or not.
75% of death sentences are over-turned on appeal.
(Appel 2005)

32. System of compensated donation is another possibility
A Register with compensation which will be the same at the savings made by the health care system from the elimination of 20 years of dialysis.$95,000 to 250,000.

33. Transplant tourism
Poverty stricken persons in developing world are organ vendors at the mercy of brokers.

34. Transplant tourism
Central Hippocratic commitment is to nonjudgmental regard. Doesn’t matter if they are enemy soldiers, prisoners, or have gone to China for transplant.
2003 : an international study on kidney transplant traffic. recipients paid $100,000 while living donors had received $800. In China kidney ,000 and liver from executed prisoner
for donors after care generally not available.

35. Liver transplants in China
20-30% have hepatitis B virus. Liver disease a leading cause of death in PRC.
China like most Asian countries has no brain death law and so almost all come from living donors.
Yet 95% of liver transplants in PRC come from deceased donors (executed prisoners).
Survival close to that in US. 70% after 5 years.
(Rhodes 2010)

36. Transplants in China or India
U.S. patients receive substandard care. Should they be treated in US? Yes ethics of medicine are strict : fiduciary responsibility: doctors are trusted agents of their patients’ welfare and beneficence.

37. Presumed consent accepted in many countries.
Individual consent not thought to be ethically necessary and it is good to conserve scarce resources.
Consent: Sweden: legally presumed but close relatives can veto donation

38. Presumed consent
To presume consent allows for the relatives of the deceased to simply confirm that donation can go ahead as opposed to undertaking the decision alone. (Cherkassky 2010)

39. Presumed consent Problems:
Undermines patient autonomy
Assumes knowledge by patient
Causes distress to relative
We could think of organ donation as a duty the dead owe to the living

40. 72 year old female, no other health problems
You are on an organ donation ethics board of your local hospital. You have just been informed that a healthy heart has just been harvested from an accident victim. This is wonderful news; however, you have four possible candidates who have all been on the heart transplant list for about a year. The candidates are as follows:
72 year old female, no other health problems
17 year old male addicted to cocaine, has been in and out of rehabilitation but refuses to comply with rehab goals
32 year old female, mother of two children (2 year old & 6 year old), 3 year breast cancer survivor
50 year old male, has diabetes, serving 30 years in prison for rape.