1. Innovassynth Technologies (India) Limited
( A knowledge based - R&D Driven –
ISO Chemical Service Company )

2. CORPORATE PROFILE

3. Promoted by Raheja Group and Ghia Group
Both the groups have interest in different business segments
Polyesters
Batteries
Construction Material
Insurance
Publication
Software
Chemicals
Etc.
Have partnership with large multinational companies across the world for many years

4. Infrastructure Area of land : 65 Acres.
R&D Labs : 5 labs for 84 Chemists who can work on bench (2 for nucleosides, 2 for Organic Synthesis &
1 for nutraceuticals)
Kilo Lab : 3 No. (2 for Nucleosides & 1 for other Organic Synthesis)
Manufacturing : 6 plants (including 2 exclusive plants for
Plants Nucleoside Products).
Exclusive Contract Manufacturing Plant for a European MNC
QC and Analytical method Development Lab
Effluent Treatment Plant

5. Nucleoside Capabilities

6. Innovassynth Advantages
15 years of experience in supplying wide variety of Nucleoside products (including PNS, phosphoramidites, succinates and specialty products)
Working with large pharmaceutical MNCs, drug discovery companies and oligo manufacturing companies from the USA, Europe and Japan
Very large scale capacity (3000 kgs) to produce in-house PNS and phosphoramidites
Unique Capabilities and Extensive experience of Large Scale Sugar as well as Nucleoside chemistry as per customer requirements
Excellent track record of quality and timeline along with competitive pricing
Innovassynth has developed many critical reagents like DMT-Cl, Tac-Cl etc. in house. and currently manufacturing in very large scale

7. Innovassynth Phosphoramidite capacities
(with standard and special protecting groups)
Deoxy amidites: dT, dCAc/Bz, dGibu / tac / dmf, dABz / tac
RNA Amidites (2’-O-TBDMS): U, CAc , Gibu, Abz
2’-OMe amidites: U, CAc / Bz, Gibu , ABz
2’-Fluoro amidites: U, CAc / Bz, Gibu, ABz
We also offer PNS & Succinates of all the nucleoside products

8. Innovassynth Nucleoside Products
cEt, LNA, ENA, L-RNA Nucleosides, Amidites and succinates (for license holders)
Succinates of all protected Nucleosides and Unylinker
Morpholino chlorophosphoramidates
ENA and UNA Phosphoramidites
Linker phosphoramidites (Biotin, 6-aminohexyl, etc.)
5-Bromo, 5-Iodo uridine/deoxyuridine, 4-Thio pyrimidine Nucleosides
Modified Sugar products starting from D-Glucose
Custom made products including some of the proprietary products which we supply only to the original inventor or their license holders
We are working with drug discovery and pharmaceutical companies developing drugs using novel technology platforms like Antisense, SiRNA, Micro-RNA, Apatamers, Speigelmers etc.

9. Deoxynucleoside products (PNS, Phosphoramidites & Succinates)
Large Scale Production capabilities of deoxyamidites (50 kg batches for PNS and 25 kg batches for amidites)
Efficient conversion of PNS to Phosphoramidites without column chromatography
Amidites qualified and approved by leading drug discovery, pharma and oligo houses
In-house production of N-Acetyl dC PNS and Amidite
Multi-kilo scale synthesis of Succinates

10. (PNS, amidites & succinates)
RNA Products
(PNS, amidites & succinates)
Synthesis and scale up (Multi-kilo level) of 2’-OTBDMS RNA
PNS, amidites & succinates
Modifications Developed:
CAc , G dmf, Apiv,
2’-CPep,
2’–Dithiomethyl protected amidite
(exclusively for an European customer)
Advantages of our Synthetic Approach:
results in exclusive 2’-isomer
diTBS intermediate allow crystallization

11. (PNS, amidites & Succinates)
2’-O-Methyl Products
(PNS, amidites & Succinates)
Synthesis and scale up of PNS, amidites & succinates
(Multi-kilo level)
Advantages of our Synthetic Approach:
results in exclusive 2’-isomer
diTBS intermediate allow crystallization
Conversion of U to C to avoid problems of 2’-alkylation of C

12. (PNS, amidites & Succinates)
2’-Fluoro products
(PNS, amidites & Succinates)
Highlights
Developed efficient and scalable processes for manufacture of 2’-Fluoro PNS, amidites & Succinates
Production of kilo-level 2’-Fluoro amidites without any column chromatography
2’-Fluoro products qualified, approved and supplied to leading pharma, drug discovery and oligo houses

13. (PNS, amidites & Succinates)
2’-MOE Products **
(PNS, amidites & Succinates)
Large scale producer for all 2’-MOE products (PNS, amidites & succinates)
MOE-pyrimidines PNS produced at 100kg lot
Developed & scaled up efficient processes for MOE- purines
B = Abz, T, GiBu, 5-Me-CBz
R = H / CEPA /
Succinate –TEA salt
MOE products qualified, approved and supplied regularly to leading pharma, drug discovery and oligo houses
We are in the supply chain of large pharma company whose product is already approved by USFDA
** For License Holders

14. cEt chemistry at Innovassynth **
Multi-kilo scale synthesis of all six cEt monomer products (A, G, U, C, T & 5-Me-C)
Very large scale synthesis of Nap-Mesylate sugar (50 kg/batch)
Convergent approach allows use of Nap-Mesyl sugar for producing all cEt monomers
Excellent manufacturing set-up to carry out large scale glycosylation reactions
Consistent and reliable supplier of cEt amidites
Working since 2009 for development, scale up and optimization of cEt amidite manufacture
** For License Holders

15. LNA chemistry at Innovassynth **
Highlights
Synthesis of all four LNA monomers
Multi-Kilo scale synthesis of Bis-Mesylate sugar
Excellent manufacturing set-up to carry out large scale glycosylation reactions
Very Large scale synthesis of key intermediates: Allofuranose & Bis Mesyl sugar
** For License Holders

16. Morpholino chlorophosphoramidates **
Highlights
Synthesis of all four chlorophosphoroamidate activated morpholino subunits
In house preparation of good quality phosphorodichloridate reagent
All the morpholino chloro- phosphoramidates approved by license holder pharma company
** For License Holders

17. Process Capabilities- Carbohydrate Chemistry
Developed 4 sugar monomers and produced on 50 kg scale.
Multistep synthesis starting from D-Glucose into a trisaccharide intermediate for generic API was achieved
Also developed large scale synthesis of many specialty Nucleosides from the respective sugars (made from D-Glucose) and glycosylating them with appropriate heterocyclic bases to prepare various Constrained Bicyclic Nucleosides (LNA, cEt, ENA) 17

18. Small Molecules Capabilities

19. Process Capabilities - Small Molecules
Grignard reactions
Handling reactions on large scale involving 100s of kgs of Mg
Safety system to take care of handling of Grignards are developed
Friedel-crafts reaction
Handling large quantities of AlCl3 for this reaction
The acidic effluent is disposed in very safe and unique manner
(It is used by large common effluent treatment plants in Industrial areas as a substitute to alum for coagulation)
Boron Chemistry
(Borates, Boronic Acids, Boron Mediated Asymmetric Synthesis)
Developed processes for many boronic acids by cheaper methods

20. Process Capabilities – Small Molecules
Cyanation (NaCN, KCN, CuCN)
Developed complete facility for this reaction including handling, charging and disposal of effluent after destruction of cyanide residue
Special precaution is taken while handling the cyanide and people are provided with all safety gadgets and training
Halogenation (Aliphatic/Aromatic)
This includes both liquid bromine handling as well as chlorine gas handling from big toners of 1 MT
Catalytic Hydrogenation 30 Bar; 1500C
We handle all types of catalysts
The noble metal catalysts are collected after use and sent for recovery

21. Process Capabilities- Small Molecules
Organometallic reactions
Developed skills to handle nBuLi in big cylinders of capacity 400 kg
Full safety systems are developed for reactions involving nBuLi
Optimized and scaled up processes for making Organometalic catalysts like zirconium complexes.
Oxidations using Metal Oxides, H2O2, Per Acids, Hypochlorite
Reductions Using Metal Hydrides, Nobel Metals, Ni, Na/ EtOH, Al Isopropoxide, Chemical Reductions
Aromatic Fluorination, Sulphonation 21

22. Few examples of our process strength and scale up capability:
Sodium-β-glycerophosphate (g2p)
Process development and scale up to ton level in 6 months
Higher capacity was achieved in existing facility by improving process parameters
Since this product is used in Pharma foarmulations and in cell cultures, it has a very high worldwide demand.
Isosulphan Blue
This is a dye used in diagnostics for cancer detection.
The chemistry involves handling of hazardous reagents like 65% oleum, dichromate solution, etc.
The purification process involves separating the product from inorganic salts.
Received US patent for the process for this product. 22

23. 7-Bromoheptene: Metallocine
This is an intermediate for a Hep C drug in clinical trial Phase III
The product is manufactured regularly as per customer requirement in ton lot quantity.
The reaction involves Grignard reaction.
Metallocine
This is a high end catalyst
Large scale reactions were carried out using 400 kg cylinders n-BuLi
Used in Polymerizations
Developed and scaled up for an international company 23

24. Thanks
&
Best Wishes