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Auris O. Huen, PharmD, MD, Ellen J. Kim, MD  Dermatologic Clinics 

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1 The Role of Systemic Retinoids in the Treatment of Cutaneous T-Cell Lymphoma 
Auris O. Huen, PharmD, MD, Ellen J. Kim, MD  Dermatologic Clinics  Volume 33, Issue 4, Pages (October 2015) DOI: /j.det Copyright © 2016 The Authors Terms and Conditions

2 Fig. 1 Retinoid receptor responses. (1) RXR forms homodimers with itself, and with ligand binding, leads to activation of transcription. (2) RXR also forms permissive heterodimers with other nuclear receptors, such as PPAR and LXR-activation of transcription occurs with binding of ligand to either receptor. (3) RXR forms nonpermissive heterodimers with RAR, TR, or VDR. Activation of transcription occurs only with ligand binding on both receptors. DR elements, direct repeat elements; TR, Thyroid hormone receptor; VDR, vitamin D3 receptor. a Ligand. Dermatologic Clinics  , DOI: ( /j.det ) Copyright © 2016 The Authors Terms and Conditions

3 Fig. 2 Recommendations for monitoring patients on systemic retinoids.
Dermatologic Clinics  , DOI: ( /j.det ) Copyright © 2016 The Authors Terms and Conditions


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