1. Vaccines

2. 1
Edward Jenner
1796
Black pox
(smallpox)
Cow pox

3. Immunization 2 Passive immunization Active immunization
Hepatitis A, B, tetanus, varicella, botulism
Active immunization

4. 3
Inactivated vaccines
live virus propagation many viruses inactivation vaccine
in cells heat, formalin purification

5. Attenuated (weakened) viruses4
Live vaccines
Attenuated (weakened) viruses
live virus propagation propagation propagation attenuated virus vaccine

6. Recombinant vaccines adenovirus vector 5 pathogen
adenovirus recombinant propagation recombinant vaccine
pathogen
virus
gene of

7. Recombinant vaccines poxvirus vector rabies 6 vaccinia virus
G protein gene
rabiesvirus
rabies
G protein-expressing
vaccinia virus [
vaccinia virus
rabies virus

8. Avian (bird) influenza virus7
Recombinant vaccines
Avian (bird) influenza virus [

9. DNA vaccines 8 antigen gene pathogen recombinant plasmid plasmid mRNA
protein
free antigen
genetic material
recombinant plasmid
muscle
skin
antigen complex
on cell surface
MHC-I
gene gun

10. 9
Subunit vaccines
peptide vaccines
antibody
antigens

11. 10
Toxoid vaccines
Clostridium tetani

12. dying HIV–infected cell
Anti-AIDS vaccine
recombinant plasmid
HIV
Gag gene
HIV
INITIAL
INJECTION
recombinant plasmid 11
muscle
adenovirus
with Gag gene
Gag protein
BOOSTER SHOT,
months later
APC
CELLULAR
IMMUNE RESPONSE
HUMORAL
IMMUNE RESPONSE
Gag protein fragment
Inactive cytotoxic
T cell
helper T cell(CD4)
activated cytotoxic
T cell
cytokines
activated
B cell
antibodies
APC: antigen presenting cell
dying HIV–infected cell

13. Edible vaccines 3rd Generation GMOs 12 Agrobacterium plant cell
recombinant
plasmid
Agrobacterium
plant cell
antibiotic
resistance
callus regeneration
Vaccine potato

14. Vaccination with mosquitos13
Vaccination with mosquitos
Leishmania sp.
Anti-Leishmaniasis vaccine in the mosquito saliva