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Nad metabolites The pyridine dinucleotide, NAD+, is a substrate of sirtuins and coenzyme for hydride transfer enzymes and other NAD+-dependent ADP ribose.

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Presentation on theme: "Nad metabolites The pyridine dinucleotide, NAD+, is a substrate of sirtuins and coenzyme for hydride transfer enzymes and other NAD+-dependent ADP ribose."— Presentation transcript:

1 nad metabolites The pyridine dinucleotide, NAD+, is a substrate of sirtuins and coenzyme for hydride transfer enzymes and other NAD+-dependent ADP ribose transfer enzymes. It is a unique cellular molecule produced from the pyridine mononucleotides nicotinic acid mononucleotide (NaMN) or nicotinamide mononucleotide (NMN). It is exist in either the form NAD+ or NADH. When being cleaved, NAD+ and NADH can convert to nicotinamide (Nam) and acetylated ADP ribose. The acetylated ADP ribose in turn can be deacetylated by sirtuins.

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