1. Date of download: 11/12/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Positron Emission Tomography Quantification of Serotonin 1A Receptor Binding in Suicide Attempters With Major Depressive Disorder JAMA Psychiatry. 2015;72(2):169-178. doi:10.1001/jamapsychiatry.2014.2406 Bivariate Plot of the Relationship Between Raphe Nuclei Serotonin 1A Binding Potential (BP F ) and Lethality Rating of the Most Recent Suicide AttemptParticipants include the 29 suicide attempters with major depressive disorder (MDD). Error bars depict associated SE; diagonal line, the fitted curve; and slope, the correlation. Lethality of the attempt was measured using the Beck Medical Lethality Scale (scores range from 0 to 6, and the scale scores to 8, which designates a fatal attempt) (F 1,25 = 10.56; P =.003; R 2 = 0.32). Displayed serotonin 1A BP F estimates have been adjusted for sex and prior antidepressant use derived from the specific linear mixed- effects model examining the relationship of raphe nuclei serotonin 1A BP F with lethality for all suicide attempters with MDD. For display purposes, 1 lower-lethality attempter with a very high serotonin 1A BP F and SE is not included in this plot but was included in all the statistical analyses. Figure Legend:

2. Date of download: 11/12/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Positron Emission Tomography Quantification of Serotonin 1A Receptor Binding in Suicide Attempters With Major Depressive Disorder JAMA Psychiatry. 2015;72(2):169-178. doi:10.1001/jamapsychiatry.2014.2406 Bivariate Plot of the Relationship Between Raphe Nuclei Serotonin 1A Binding Potential (BP F ) and the Beck Suicide Intent Scale Factor 1 Score in Suicide AttemptersParticipants include the 29 suicide attempters with major depressive disorder (MDD). Error bars depict associated SE; diagonal line, best fit; and slope, correlation. Factor 1 indicates lethal intent (scores range from 0 to 12) (F 1,25 = 10.63; P =.003; R 2 = 0.32). Displayed serotonin 1A BP F estimates have been adjusted for sex and prior antidepressant medication status derived from the specific linear mixed-effects model examining the relationship of raphe nuclei serotonin 1A BP F with the factor 1 score in all suicide attempters with MDD. For display purposes, 1 lower-lethality attempter with a very high serotonin 1A BP F and SE is not included in this plot but was included in all the statistical analyses. Figure Legend:

3. Date of download: 11/12/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Positron Emission Tomography Quantification of Serotonin 1A Receptor Binding in Suicide Attempters With Major Depressive Disorder JAMA Psychiatry. 2015;72(2):169-178. doi:10.1001/jamapsychiatry.2014.2406 Bivariate Plot of the Relationship Between Raphe Nuclei Serotonin 1A Binding Potential (BP F ) and the Beck Scale for Suicide Ideation Score in All ParticipantsParticipants include the 91 patients with major depressive disorder (MDD). Error bars depict associated SE; diagonal line, best fit; and slope, correlation. Suicidal ideation scores in the 2 weeks before positron emission tomography range from 0 to 30 (F 1,87 = 7.38; P =.008; R 2 = 0.12). Displayed serotonin 1A BP F estimates have been adjusted for sex and prior antidepressant use derived from the specific linear mixed-effects model examining the relationship of raphe nuclei serotonin 1A BP F with the Beck Scale for Suicide Ideation score in all participants with MDD. For display purposes, 1 lower-lethality attempter with a very high serotonin 1A BP F and SE is not included in this plot but was included in all the statistical analyses. Figure Legend: